Breast cancer is the most commonly diagnosed cancer in women worldwide, and> 90% of
breast cancer-related deaths are associated with metastasis. Breast cancer spreads …

A growing body of work has shown that cancer metastasis is not a random spontaneous
event; rather, it is the culmination of a cascade of priming steps through which a …

Cell membrane coating has recently emerged as a promising biomimetic approach to
engineering nanoparticles (NPs) for targeted drug delivery. However, simple cell membrane …

Tumor-associated macrophages (TAMs) play an essential role in metastasis. However, what
enables TAMs to have a superior capacity to establish pre-metastatic microenvironment in …

Breast cancer brain metastasis (BCBM) is a devastating disease. Radiation therapy remains
the mainstay for treatment of this disease. Unfortunately, its efficacy is limited by the dose …

Stroke is a deadly disease without effective pharmacotherapies, which is due to two major
reasons. First, most therapeutics cannot efficiently penetrate the brain. Second, single agent …

Ischemic stroke is a leading cause of death and disability and remains without effective
treatment options. Improved treatment of stroke requires efficient delivery of multimodal …

Oral drug delivery, which requires surviving the harsh environment in the gastrointestinal
(GI) tract and penetrating the intestinal epithelium, has not been achieved using simple …

Breast cancer brain metastases (BCBM) is a devastating disease with dismal prognosis.
Although chemotherapy is widely used for clinical management of most tumors, it is often …

Breast cancer brain metastases (BCBMs) represent a major cause of morbidity and mortality
among patients with breast cancer. Chemotherapy, which is widely used to treat tumors …