Molecular mechanisms of breast cancer metastasis to the lung: clinical and experimental perspectives
B Medeiros, AL Allan - International journal of molecular sciences, 2019 - mdpi.com
Breast cancer is the most commonly diagnosed cancer in women worldwide, and> 90% of
breast cancer-related deaths are associated with metastasis. Breast cancer spreads …
breast cancer-related deaths are associated with metastasis. Breast cancer spreads …
Cancer tills the premetastatic field: mechanistic basis and clinical implications
A growing body of work has shown that cancer metastasis is not a random spontaneous
event; rather, it is the culmination of a cascade of priming steps through which a …
event; rather, it is the culmination of a cascade of priming steps through which a …
Targeted drug delivery to stroke via chemotactic recruitment of nanoparticles coated with membrane of engineered neural stem cells
Cell membrane coating has recently emerged as a promising biomimetic approach to
engineering nanoparticles (NPs) for targeted drug delivery. However, simple cell membrane …
engineering nanoparticles (NPs) for targeted drug delivery. However, simple cell membrane …
CYP4A in tumor-associated macrophages promotes pre-metastatic niche formation and metastasis
XW Chen, TJ Yu, J Zhang, Y Li, HL Chen, GF Yang… - Oncogene, 2017 - nature.com
Tumor-associated macrophages (TAMs) play an essential role in metastasis. However, what
enables TAMs to have a superior capacity to establish pre-metastatic microenvironment in …
enables TAMs to have a superior capacity to establish pre-metastatic microenvironment in …
LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy
Y Chen, T Jiang, H Zhang, X Gou, C Han, J Wang… - Nature cell …, 2020 - nature.com
Breast cancer brain metastasis (BCBM) is a devastating disease. Radiation therapy remains
the mainstay for treatment of this disease. Unfortunately, its efficacy is limited by the dose …
the mainstay for treatment of this disease. Unfortunately, its efficacy is limited by the dose …
[HTML][HTML] Anti-edema and antioxidant combination therapy for ischemic stroke via glyburide-loaded betulinic acid nanoparticles
Stroke is a deadly disease without effective pharmacotherapies, which is due to two major
reasons. First, most therapeutics cannot efficiently penetrate the brain. Second, single agent …
reasons. First, most therapeutics cannot efficiently penetrate the brain. Second, single agent …
Brain targeting, antioxidant polymeric nanoparticles for stroke drug delivery and therapy
Ischemic stroke is a leading cause of death and disability and remains without effective
treatment options. Improved treatment of stroke requires efficient delivery of multimodal …
treatment options. Improved treatment of stroke requires efficient delivery of multimodal …
Single small molecule-assembled nanoparticles mediate efficient oral drug delivery
Oral drug delivery, which requires surviving the harsh environment in the gastrointestinal
(GI) tract and penetrating the intestinal epithelium, has not been achieved using simple …
(GI) tract and penetrating the intestinal epithelium, has not been achieved using simple …
Targeted Delivery of Secretory Promelittin via Novel Poly(lactone‐co‐β‐amino ester) Nanoparticles for Treatment of Breast Cancer Brain Metastases
Y Zhou, S Zhang, Z Chen, Y Bao, AT Chen… - Advanced …, 2020 - Wiley Online Library
Breast cancer brain metastases (BCBM) is a devastating disease with dismal prognosis.
Although chemotherapy is widely used for clinical management of most tumors, it is often …
Although chemotherapy is widely used for clinical management of most tumors, it is often …
Autocatalytic Delivery of Brain Tumor–Targeting, Size‐Shrinkable Nanoparticles for Treatment of Breast Cancer Brain Metastases
Breast cancer brain metastases (BCBMs) represent a major cause of morbidity and mortality
among patients with breast cancer. Chemotherapy, which is widely used to treat tumors …
among patients with breast cancer. Chemotherapy, which is widely used to treat tumors …