PARP inhibitors: clinical relevance, mechanisms of action and tumor resistance
The Poly (ADP-ribose) polymerase (PARP) family has many essential functions in cellular
processes, including the regulation of transcription, apoptosis and the DNA damage …
processes, including the regulation of transcription, apoptosis and the DNA damage …
Shaping the BRCAness mutational landscape by alternative double-strand break repair, replication stress and mitotic aberrancies
C Stok, YP Kok, N van den Tempel… - Nucleic acids …, 2021 - academic.oup.com
Tumours with mutations in the BRCA1/BRCA2 genes have impaired double-stranded DNA
break repair, compromised replication fork protection and increased sensitivity to replication …
break repair, compromised replication fork protection and increased sensitivity to replication …
ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination-deficient cells
The response to poly (ADP-ribose) polymerase inhibitors (PARPi) is dictated by homologous
recombination (HR) DNA repair and the abundance of lesions that trap PARP enzymes. It …
recombination (HR) DNA repair and the abundance of lesions that trap PARP enzymes. It …
Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors
K Fugger, I Bajrami, M Silva Dos Santos, SJ Young… - Science, 2021 - science.org
Mutations in the BRCA1 or BRCA2 tumor suppressor genes predispose individuals to breast
and ovarian cancer. In the clinic, these cancers are treated with inhibitors that target poly …
and ovarian cancer. In the clinic, these cancers are treated with inhibitors that target poly …
Replication gaps underlie BRCA deficiency and therapy response
NJ Panzarino, JJ Krais, K Cong, M Peng, M Mosqueda… - Cancer research, 2021 - AACR
Defects in DNA repair and the protection of stalled DNA replication forks are thought to
underlie the chemosensitivity of tumors deficient in the hereditary breast cancer genes …
underlie the chemosensitivity of tumors deficient in the hereditary breast cancer genes …
Inhibition of the translesion synthesis polymerase REV1 exploits replication gaps as a cancer vulnerability
The replication stress response, which serves as an anticancer barrier, is activated not only
by DNA damage and replication obstacles but also oncogenes, thus obscuring how cancer …
by DNA damage and replication obstacles but also oncogenes, thus obscuring how cancer …
The emerging determinants of replication fork stability
T Thakar, GL Moldovan - Nucleic acids research, 2021 - academic.oup.com
A universal response to replication stress is replication fork reversal, where the nascent
complementary DNA strands are annealed to form a protective four-way junction allowing …
complementary DNA strands are annealed to form a protective four-way junction allowing …
[HTML][HTML] PARP1: Structural insights and pharmacological targets for inhibition
Abstract Poly (ADP-ribose) polymerase 1 (PARP1, also known as ADPRT1) is a
multifunctional human ADP-ribosyltransferase. It plays a role in multiple DNA repair …
multifunctional human ADP-ribosyltransferase. It plays a role in multiple DNA repair …
To skip or not to skip: choosing repriming to tolerate DNA damage
Accurate DNA replication is constantly threatened by DNA lesions arising from endogenous
and exogenous sources. Specialized DNA replication stress response pathways ensure …
and exogenous sources. Specialized DNA replication stress response pathways ensure …
Biochemical and structural basis for YTH domain of human YTHDC1 binding to methylated adenine in DNA
The recently characterized mammalian writer (methyltransferase) and eraser (demethylase)
of the DNA N6-methyladenine (N6mA) methyl mark act on single-stranded (ss) and …
of the DNA N6-methyladenine (N6mA) methyl mark act on single-stranded (ss) and …