Systemic immunoglobulin light chain amyloidosis

G Merlini, A Dispenzieri, V Sanchorawala… - Nature reviews Disease …, 2018 - nature.com
Systemic immunoglobulin light chain amyloidosis is a protein misfolding disease caused by
the conversion of immunoglobulin light chains from their soluble functional states into highly …

Immunoglobulin light chain amyloidosis: 2020 update on diagnosis, prognosis, and treatment

MA Gertz - American journal of hematology, 2020 - Wiley Online Library
Abstract Disease Overview Immunoglobulin light chain amyloidosis is a clonal,
nonproliferative plasma cell disorder in which fragments of immunoglobulin light or heavy …

Guidelines for high dose chemotherapy and stem cell transplantation for systemic AL amyloidosis: EHA-ISA working group guidelines

V Sanchorawala, M Boccadoro, M Gertz, U Hegenbart… - Amyloid, 2022 - Taylor & Francis
AL amyloidosis is a systemic amyloidosis and is associated with an underlying plasma cell
dyscrasia. High dose intravenous melphalan and autologous stem cell transplantation was …

Improved outcomes after autologous hematopoietic cell transplantation for light chain amyloidosis: a Center for International Blood and Marrow Transplant Research …

A D'Souza, A Dispenzieri, B Wirk, MJ Zhang… - Journal of Clinical …, 2015 - ascopubs.org
Purpose Autologous hematopoietic cell transplantation, or autotransplantation, is effective in
light-chain amyloidosis (AL), but it is associated with a high risk of early mortality (EM). In a …

Treatment of AL amyloidosis: Mayo stratification of myeloma and risk-adapted therapy (mSMART) consensus statement 2020 update

E Muchtar, A Dispenzieri, MA Gertz, SK Kumar… - Mayo Clinic …, 2021 - Elsevier
Immunoglobulin light chain (AL) amyloidosis is a clonal plasma cell disorder leading to
progressive and life-threatening organ failure. The heart and the kidneys are the most …

Immunoglobulin light chain amyloidosis: 2016 update on diagnosis, prognosis, and treatment

MA Gertz - American journal of hematology, 2016 - Wiley Online Library
Disease Overview Immunoglobulin light chain amyloidosis is a clonal, nonproliferative
plasma cell disorder in which fragments of immunoglobulin light chain are deposited in …

Immunoglobulin light chain amyloidosis: 2018 Update on diagnosis, prognosis, and treatment

MA Gertz - American journal of hematology, 2018 - Wiley Online Library
Abstract Disease Overview Immunoglobulin light chain amyloidosis is a clonal,
nonproliferative plasma cell disorder in which fragments of immunoglobulin light or heavy …

Advances in the treatment of cardiac amyloidosis

AVS Macedo, PV Schwartzmann… - … treatment options in …, 2020 - Springer
Opinion statement Cardiac amyloidosis is associated with a high mortality rate, a long delay
between the first signs and the diagnosis but a short interval between diagnosis and death …

Immunoglobulin light chain amyloidosis

G Merlini, RL Comenzo, DC Seldin… - Expert review of …, 2014 - Taylor & Francis
Primary light chain amyloidosis is the most common form of systemic amyloidosis and is
caused by misfolded light chains that cause proteotoxicity and rapid decline of vital organ …

Immunoglobulin light chain amyloidosis: 2014 update on diagnosis, prognosis, and treatment

MA Gertz - American journal of hematology, 2014 - Wiley Online Library
Disease Overview: Immunoglobulin light chain amyloidosis is a clonal, nonproliferative
plasma cell disorder in which fragments of immunoglobulin light chain are deposited in …