Recombinant antibodies currently represent over 30% of biopharmaceuticals in clinical
trials, highlighted by the recent Food and Drug Administration (FDA) approvals of …

Bovine β-lactoglobulin (βLG) has been one of the most extensively studied proteins in the
history of protein science mainly because its abundance in cow's milk makes it readily …

Importance of the field: Targeted liposomal drugs represent the next evolution of liposomal
drug delivery in cancer treatment. In various preclinical cancer models, antibody-targeted …

The variable (V) domains of antibodies and T cell receptors (TCRs) share sequence
homology and striking structural similarity. Single-chain antibody V domain constructs (scFv) …

The periplasmic seventeen kilodalton protein (Skp) chaperone has been characterized
primarily for its role in outer membrane protein (OMP) biogenesis, during which the jellyfish …

Antibodies are uniquely suited to serve essential roles in the human immune defense as
they combine several specific functions in one hetero-oligomeric protein. Their constant …

Here we investigate how thermodynamic properties of orthologous proteins are influenced
by the genomic environment in which they evolve. We performed a comparative …

The human epidermal growth factor receptor (HER) family plays an important role in cell
growth and signaling and alteration of its function has been demonstrated in many different …

Disulfide bridges are one of the most important factors stabilizing the native structure of a
protein. Whereas the basis for their stabilizing effect is well understood, their role in a protein …

Antibody-targeted liposomal anticancer drugs combine the specificity of antibodies with
large payloads of entrapped drugs. We previously showed that liposomal doxorubicin (DXR) …