Tolerance and innate immunity shape the development of postpartum uterine disease and the impact of endometritis in dairy cattle

IM Sheldon, JG Cronin… - Annual review of animal …, 2019 - annualreviews.org
Bacteria are ubiquitous in the bovine uterus after parturition, but 50 years ago, cows
tolerated these bacteria and few animals developed uterine disease. Now, up to 40% of …

Persistent breeding-induced endometritis in mares—A multifaceted challenge: From clinical aspects to immunopathogenesis and pathobiology

IF Canisso, LGTM Segabinazzi… - International journal of …, 2020 - mdpi.com
Post-breeding endometritis (ie, inflammation/infection of the endometrium), is a
physiological reaction taking place in the endometrium of mares within 48 h post-breeding …

A review of the ongoing discussion about definition, diagnosis and pathomechanism of subclinical endometritis in dairy cows

K Wagener, C Gabler, M Drillich - Theriogenology, 2017 - Elsevier
In the last decade, several new aspects of the inflammation of the bovine endometrium have
been investigated and described, including a new definition of subclinical endometritis. This …

Postpartum uterine infection and endometritis in dairy cattle

IM Sheldon, SE Owens - Animal Reproduction (AR), 2018 - animal-reproduction.org
After parturition, uterine involution, regeneration of the endometrium, return of ovarian cyclic
activity, and the control of pathogenic bacteria in the uterus is required before cows are likely …

Survival factors regulating ovarian apoptosis--dependence on follicle differentiation

E Markstrom, EC Svensson, R Shao… - …, 2002 - rep.bioscientifica.com
Epigenetic reprogramming plays a pivotal role during embryogenesis, including both
covalent and non-covalent modifications to chromatin. In this study, we investigated the role …

Preventing postpartum uterine disease in dairy cattle depends on avoiding, tolerating and resisting pathogenic bacteria

IM Sheldon, PCC Molinari, TJR Ormsby, JJ Bromfield - Theriogenology, 2020 - Elsevier
Up to forty percent of dairy cows develop metritis or endometritis when pathogenic bacteria
infect the uterus after parturition. However, resilient cows remain healthy even when …

[HTML][HTML] Particulate matter induces inflammatory cytokine production via activation of NFκB by TLR5-NOX4-ROS signaling in human skin keratinocyte and mouse skin

YS Ryu, KA Kang, MJ Piao, MJ Ahn, JM Yi, YM Hyun… - Redox biology, 2019 - Elsevier
Particulate matter (PM) increases levels of pro-inflammatory cytokines, but its effects on the
skin remain largely unknown. We investigated the signal transduction pathway and …

Mechanisms linking bacterial infections of the bovine endometrium to disease and infertility

LC Carneiro, JG Cronin, IM Sheldon - Reproductive biology, 2016 - Elsevier
Bacterial infections of the endometrium after parturition commonly cause metritis and
endometritis in dairy cattle, and these diseases are important because they compromise …

Innate immunity and inflammation of the bovine female reproductive tract in health and disease

IM Sheldon, JG Cronin, GD Healey, C Gabler… - …, 2014 - rep.bioscientifica.com
In mammals, the sperm activates the development of the egg by triggering a series of
oscillations in the cytosolic-free Ca 2+ concentration (Ca 2+ i). The sperm triggers these …

Epithelial and stromal cells of bovine endometrium have roles in innate immunity and initiate inflammatory responses to bacterial lipopeptides in vitro via Toll-like …

ML Turner, JG Cronin, GD Healey, IM Sheldon - Endocrinology, 2014 - academic.oup.com
Bacteria often infect the endometrium of cattle to cause endometritis, uterine disease, and
infertility. Lipopeptides are commonly found among bacteria and are detected by the Toll …