Substantial progress in understanding mechanisms of immune regulation in allergy, asthma,
autoimmune diseases, tumors, organ transplantation and chronic infections has led to a …

House dust mites (HDM; Dermatophagoides sp.) are one of the commonest aeroallergens
worldwide and up to 85% of asthmatics are typically HDM allergic. Allergenicity is …

While oral desensitization is capable of alleviating peanut allergen anaphylaxis, long-term
immune tolerance is the sought-after goal. We developed a liver-targeting lipid nanoparticle …

In the past, numerous methods have been developed to predict MHC class II binders or T-
helper epitopes for designing the epitope-based vaccines against pathogens. In contrast …

Celiac disease is a genetic condition that results in a debilitating immune reaction in the gut
to antigens in grain. The antigenic peptides recognized by the T cells that cause this disease …

Allergen-specific immunotherapy has been used for 100 years as a desensitizing therapy for
allergic diseases and represents the potentially curative and specific method of treatment …

Allergy is a Th2‐mediated disease that involves the formation of specific IgE antibodies
against innocuous environmental substances. The prevalence of allergic diseases has …

Current therapies for asthma and allergy are relatively safe and effective at controlling
symptoms but do not change the chronic course of disease. There is no established method …

Asthma is characterized by T helper cell 2 (Th2) type inflammation, leading to airway
hyperresponsiveness and tissue remodeling. Th2 cell-driven inflammation is likely to …

During the past 20 years, major advances have been made in understanding the molecular
and cellular mechanisms of allergen tolerance in humans. The demonstration of T cell …