Transient receptor potential (TRP) channels are multifunctional signalling molecules with
many roles in sensory perception and cellular physiology. Therefore, it is not surprising that …

Obesity contributes to reduced life expectancy, impaired quality of life, and disabilities,
mainly in those individuals who develop cardiovascular diseases, type 2 diabetes …

Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

The hypothalamus is key in the control of energy balance. However, strategies targeting
hypothalamic neurons have failed to provide viable options to treat most metabolic diseases …

Imaging is an essential tool in research, diagnostics and the management of endocrine
disorders. Ultrasonography, nuclear medicine techniques, MRI, CT and optical methods are …

The transient receptor potential melastatin subtype 8 (TRPM8) is a nonselective, multimodal
ion channel, activated by low temperatures (< 28° C), pressure, and cooling compounds …

Cytisine, a natural bioactive compound that is mainly isolated from plants of the
Leguminosae family (especially the seeds of Laburnum anagyroides), has been marketed in …

In the last thirty years, obesity has reached epidemic proportions and is now regarded as a
major health issue in contemporary society trending to serious economic and social …

Brown and brite adipocytes contribute to energy expenditure through nonshivering
thermogenesis. Though these cell types are thought to arise primarily from the de novo …

Thermal homeostasis is a fundamental process in mammals, which allows the maintenance
of a constant internal body temperature to ensure an efficient function of cells despite …