Bioinspired out-of-equilibrium systems will set the scene for the next generation of molecular
materials with active, adaptive, autonomous, emergent and intelligent behavior. Indeed life …

Membrane protrusions at the leading edge of cells, known as lamellipodia, drive cell
migration in many normal and pathological situations. Lamellipodial protrusion is powered …

Stimuli that promote cell migration, such as chemokines, cytokines, and growth factors in
metazoans and cyclic AMP in Dictyostelium, activate signaling pathways that control …

Praise for the first edition:… superb, beautifully written and organized work that takes an
engineering approach to systems biology. Alon provides nicely written appendices to …

Actin dynamics in cell motility, division, and phagocytosis is regulated by complex factors
with multiple feedback loops, often leading to emergent dynamic patterns in the form of …

Little is known about how neutrophils and other cells establish a single zone of actin
assembly during migration. A widespread assumption is that the leading edge prevents …

Actin is the main protein used by biological cells to adapt their structure and mechanics to
their needs. Cellular adaptation is made possible by molecular processes that strongly …

During cell migration and polarization, numerous signal transduction and cytoskeletal
components self-organize to generate localized protrusions. Although biochemical and …

Chemokines are pivotal regulators of cell migration during continuous immune surveillance,
inflammation, homeostasis, and development. Chemokine binding to their 7-transmembrane …

Chemotaxis, or directed migration of cells along a chemical gradient, is a highly coordinated
process that involves gradient sensing, motility, and polarity. Most of our understanding of …