Mammalian cells have developed dedicated molecular mechanisms to tightly control
expression levels of their genes where the specific transcriptomic signature across all genes …

Since the 1970s, the emergence and expansion of novel methods for calcium ion (Ca2+)
detection have found diverse applications in vitro and in vivo across a series of model …

Alternative splicing (AS) is emerging as a critical co‐transcriptional regulation for plants in
response to environmental stresses. Although multiple splicing factors have been linked to …

MicroRNAs (miRNAs) play crucial roles in regulating plant development and stress
responses. However, the functions and mechanism of intronic miRNAs in plants are poorly …

The need for holistic molecular measurements to better understand disease initiation,
development, diagnosis, and therapy has led to an increasing number of multiomic …

Ionotropic glutamate receptors (iGluRs) play key roles for signaling in the central nervous
system. Alternative splicing and RNA editing are well-known mechanisms to increase iGluR …

To identify and annotate transcript isoforms in the chicken genome, we generated Nanopore
long-read sequencing data from 68 samples that encompassed 19 diverse tissues collected …

Precise and reliable cell-specific gene delivery remains technically challenging. Here we
report a splicing-based approach for controlling gene expression whereby separate …

Multi-input logic gene circuits can enable sophisticated control of cell function, yet large-
scale synthetic circuitry in mammalian cells has relied on post-transcriptional regulation or …

Alternative splicing (AS) is a gene regulatory mechanism modulating gene expression in
multiple ways. AS is prevalent in all eukaryotes including plants. AS generates two or more …