The circadian machinery links metabolic disorders and depression: a review of pathways, proteins and potential pharmacological interventions
Circadian rhythms are responsible for regulating a number of physiological processes. The
central oscillator is located within the suprachiasmatic nucleus (SCN) of the hypothalamus …
central oscillator is located within the suprachiasmatic nucleus (SCN) of the hypothalamus …
Concentration‐QTc Modeling of the DPP‐4 Inhibitor HSK7653 in a First‐in‐Human Study of Chinese Healthy Volunteers
X Wang, H Liu, C Cui, X Niu, H Li, S Niu… - Clinical …, 2024 - Wiley Online Library
Cofrogliptin (HSK7653) is a long‐acting dipeptidyl peptidase‐4 inhibitor for the treatment of
type 2 diabetes mellitus with a twice‐monthly dosing regimen. This study included 62 …
type 2 diabetes mellitus with a twice‐monthly dosing regimen. This study included 62 …
Assumption checking before application of the prespecified QT linear mixed effect model is essential
D Rekić, J Parkinson, H Kimko - CPT: Pharmacometrics & Systems …, 2020 - ncbi.nlm.nih.gov
In the paper, titled “Evaluation of QT Liability for PF-05251749 in the Presence of Potential
Circadian Rhythm Modification,” 1 the authors presented results from assessment of QT …
Circadian Rhythm Modification,” 1 the authors presented results from assessment of QT …
Response Letter to the Editor:“Assumption Checking Before Application of the Prespecified QT Linear Mixed Effect Model is Essential”
Y Huh, S Riley, T Nicholas - CPT: Pharmacometrics & Systems …, 2020 - ncbi.nlm.nih.gov
To the Editor: In the Letter to the Editor regarding:“Assumption checking is essential,” the
authors questioned satisfaction of assumptions required for applying the prespecified linear …
authors questioned satisfaction of assumptions required for applying the prespecified linear …