In mammals, seven members of the sirtuin protein family known as class III histone
deacetylase have been identified for their characteristic features. These distinguished …

Sirtuins are an evolutionary conserved family of NAD+-dependent protein lysine deacylases.
Mammals have seven Sirtuin isoforms, Sirt1–7. They contribute to regulation of metabolism …

Alveolar epithelial cell (AEC) mitochondrial dysfunction and apoptosis are important in
idiopathic pulmonary fibrosis and asbestosis. Sirtuin 3 (SIRT3) detoxifies mitochondrial …

B cell malignancies comprise a diverse group of cancers that proliferate in lymph nodes,
bone marrow, and peripheral blood. SIRT3 (sirtuin 3) is the major deacetylase within the …

Melanoma, the most aggressive form of skin cancer, is often fatal if not treated early.
Therefore, novel target-based strategies are required to combat this neoplasm. The …

The past few decades have witnessed a furious attention of scientific community toward
identifying novel molecular factors and targets that could be exploited for drug development …

The mammalian sirtuin family consists of seven proteins, three of which (SIRT3, SIRT4, and
SIRT5) localise specifically within mitochondria and preserve mitochondrial function and …

Abstract Sirtuin 3 (SIRT3) modulates mitochondria-localized processes and is implicated in
the metabolic reprogramming of cancer cells, especially fatty acid (FA) synthesis. However …

Background: The survival rate of patients with head and neck squamous cell carcinoma
(HNSCC) stands at approximately 50% and this has not improved in decades. This study …

SIRT3, a class III histone deacetylase, has been implicated in various cancers as a novel
therapeutic target. In hepatocellular carcinoma (HCC), we previously reported that SIRT3 …