Cellular plasticity and the neuroendocrine phenotype in prostate cancer
The success of next-generation androgen receptor (AR) pathway inhibitors, such as
abiraterone acetate and enzalutamide, in treating prostate cancer has been hampered by …
abiraterone acetate and enzalutamide, in treating prostate cancer has been hampered by …
[HTML][HTML] Recent advances in repurposing disulfiram and disulfiram derivatives as copper-dependent anticancer agents
V Kannappan, M Ali, B Small, G Rajendran… - Frontiers in Molecular …, 2021 - frontiersin.org
Copper (Cu) plays a pivotal role in cancer progression by acting as a co-factor that regulates
the activity of many enzymes and structural proteins in cancer cells. Therefore, Cu-based …
the activity of many enzymes and structural proteins in cancer cells. Therefore, Cu-based …
Disulfiram: a novel repurposed drug for cancer therapy
C Lu, X Li, Y Ren, X Zhang - Cancer chemotherapy and pharmacology, 2021 - Springer
Cancer is a major health issue worldwide and the global burden of cancer is expected to
reduce the costs of treatment as well as prolong the survival time. One of the promising …
reduce the costs of treatment as well as prolong the survival time. One of the promising …
Repurposing of drugs: An attractive pharmacological strategy for cancer therapeutics
A Kirtonia, K Gala, SG Fernandes, G Pandya… - Seminars in cancer …, 2021 - Elsevier
Human malignancies are one of the major health-related issues though out the world and
anticipated to rise in the future. The development of novel drugs/agents requires a huge …
anticipated to rise in the future. The development of novel drugs/agents requires a huge …
Toward precision medicine in glioblastoma: the promise and the challenges
Integrated sequencing strategies have provided a broader understanding of the genomic
landscape and molecular classifications of multiple cancer types and have identified various …
landscape and molecular classifications of multiple cancer types and have identified various …
Disulfiram when combined with copper enhances the therapeutic effects of temozolomide for the treatment of glioblastoma
Purpose: Glioblastoma is one of the most lethal cancers in humans, and with existing
therapy, survival remains at 14.6 months. Current barriers to successful treatment include …
therapy, survival remains at 14.6 months. Current barriers to successful treatment include …
[HTML][HTML] Disulfiram: mechanisms, applications, and challenges
J Lanz, N Biniaz-Harris, M Kuvaldina, S Jain, K Lewis… - Antibiotics, 2023 - mdpi.com
Background: Since disulfiram's discovery in the 1940s and its FDA approval for alcohol use
disorder, other indications have been investigated. This review describes potential clinical …
disorder, other indications have been investigated. This review describes potential clinical …
[HTML][HTML] New drugs are not enough‑drug repositioning in oncology: An update
RG Armando… - … Journal of Oncology, 2020 - spandidos-publications.com
Drug repositioning refers to the concept of discovering novel clinical benefits of drugs that
are already known for use treating other diseases. The advantages of this are that several …
are already known for use treating other diseases. The advantages of this are that several …
Drug-repositioning opportunities for cancer therapy: novel molecular targets for known compounds
Highlights•De novo anticancer drug discovery is challenging and repurposing in oncology is
a promising field.•Drug repositioning increasingly emerges as faster, cheaper and …
a promising field.•Drug repositioning increasingly emerges as faster, cheaper and …
[HTML][HTML] Disulfiram targets cancer stem-like cells and reverses resistance and cross-resistance in acquired paclitaxel-resistant triple-negative breast cancer cells
P Liu, IS Kumar, S Brown, V Kannappan… - British journal of …, 2013 - nature.com
Background: Triple-negative breast cancer (TNBC) has significantly worse prognosis.
Acquired chemoresistance remains the major cause of therapeutic failure of TNBC. In clinic …
Acquired chemoresistance remains the major cause of therapeutic failure of TNBC. In clinic …