For nearly 50 years the proximal tubule (PT) has been known to reabsorb, process, and
either catabolize or transcytose albumin from the glomerular filtrate. Innovative techniques …

Nutritional Management of Chronic Kidney Disease | New England Journal of Medicine Skip to
main content The New England Journal of Medicine homepage Advanced Search SEARCH …

In this narrative review, the biological/biochemical impact (toxicity) of a large array of known
individual uremic retention solutes and groups of solutes is summarized. We classified these …

Increased life expectancy is posing unprecedented challenges to healthcare systems
worldwide. These include a sharp increase in the prevalence of chronic kidney disease …

Renal nitrogen metabolism primarily involves urea and ammonia metabolism, and is
essential to normal health. Urea is the largest circulating pool of nitrogen, excluding nitrogen …

Early detection and accurate monitoring of chronic kidney disease (CKD) could improve
care and retard progression to end-stage renal disease. Here, using untargeted …

The heart and the vascular tree undergo major structural and functional changes when
kidney function declines and renal replacement therapy is required. The many …

Patients with chronic kidney disease and end-stage renal disease are at 5-to 10-fold higher
risk for developing cardiovascular disease (CVD) than age-matched controls. Clinically …

Aging is a progressive process determined by genetic and acquired factors. Among the latter
are the chemical reactions referred to as nonenzymatic posttranslational modifications …

Staphylococcus aureus bacteremia (SaB) causes significant disease in humans, carrying
mortality rates of∼ 25%. The ability to rapidly predict SaB patient responses and guide …