Plasminogen activation is regulated by the interaction between urokinase-type plasminogen
activator (uPA) and its specific glycolipid-anchored cell surface receptor (uPAR). uPAR is …

The nicotinic acetylcholine receptor (AChR) presents two very well differentiated domains for
ligand binding that account for different cholinergic properties. In the hydrophilic …

Long chain and short chain curaremimetic toxins from snakes possess 66–74 residues with
five disulfide bonds and 60–62 residues with four disulfide bonds, respectively. Despite their …

Out of about 2,340 species of snakes living on the earth, more than 420 species are
venomous (Dowling and Duellman, 1978). The venoms of proteroglyphous or fixed …

To study the site by which erabutoxin a (Ea) from Laticauda semifasciata binds to the
nicotinic acetylcholine receptor, we mutated most residues that are shared with other …

α-Cobratoxin, a long chain curaremimetic toxin from Naja kaouthia venom, was produced
recombinantly (rα-Cbtx) from Escherichia coli. It was indistinguishable from the snake toxin …

Disulfide-bound dimers of three-fingered toxins have been discovered in the Naja kaouthia
cobra venom; that is, the homodimer of α-cobratoxin (a long-chain α-neurotoxin) and …

Peptides corresponding to portions of loop 2 of snake venom curare‐mimetic neurotoxins
and to a structually similar region of rabies virus glycoprotein were synthesized. Interaction …

The crystal structure of the “long” alpha-neurotoxin alpha-cobratoxin was refined to an R-
factor of 19.5% using 3271 x-ray data to 2.4-A resolution. The polypeptide chain forms three …

A region of the alpha subunit of the nicotinic acetylcholine receptor containing the alpha-
bungarotoxin-binding domain was mapped on the primary amino acid sequence in relation …