[HTML][HTML] Neuronal excitation/inhibition imbalance: core element of a translational perspective on Alzheimer pathophysiology
Our incomplete understanding of the link between Alzheimer's Disease pathology and
symptomatology is a crucial obstacle for therapeutic success. Recently, translational studies …
symptomatology is a crucial obstacle for therapeutic success. Recently, translational studies …
Astrocyte dysfunction in Alzheimer disease
C Acosta, HD Anderson… - Journal of neuroscience …, 2017 - Wiley Online Library
Astrocytes are glial cells that are distributed throughout the central nervous system in an
arrangement optimal for chemical and physical interaction with neuronal synapses and …
arrangement optimal for chemical and physical interaction with neuronal synapses and …
Genetic variants in Alzheimer disease—molecular and brain network approaches
Genetic studies in late-onset Alzheimer disease (LOAD) are aimed at identifying core
disease mechanisms and providing potential biomarkers and drug candidates to improve …
disease mechanisms and providing potential biomarkers and drug candidates to improve …
Bits from brains for biologically inspired computing
Inspiration for artificial biologically inspired computing is often drawn from neural systems.
This article shows how to analyze neural systems using information theory with the aim of …
This article shows how to analyze neural systems using information theory with the aim of …
Bridging scales in Alzheimer's disease: biological framework for brain simulation with the virtual brain
Despite the acceleration of knowledge and data accumulation in neuroscience over the last
years, the highly prevalent neurodegenerative disease of AD remains a growing problem …
years, the highly prevalent neurodegenerative disease of AD remains a growing problem …
Trigeminal, visceral and vestibular inputs may improve cognitive functions by acting through the locus coeruleus and the ascending reticular activating system: a new …
V De Cicco, MP Tramonti Fantozzi, E Cataldo… - Frontiers in …, 2018 - frontiersin.org
It is known that sensory signals sustain the background discharge of the ascending reticular
activating system (ARAS) which includes the noradrenergic locus coeruleus (LC) neurons …
activating system (ARAS) which includes the noradrenergic locus coeruleus (LC) neurons …
Tau and amyloid-related pathologies in the entorhinal cortex have divergent effects in the hippocampal circuit
SL Angulo, R Orman, SA Neymotin, L Liu… - Neurobiology of …, 2017 - Elsevier
The entorhinal cortex (EC) is affected early in Alzheimer's disease, an illness defined by a co-
occurrence of tau and amyloid-related pathologies. How the co-occurrence of these …
occurrence of tau and amyloid-related pathologies. How the co-occurrence of these …
The impact of mathematical modeling in understanding the mechanisms underlying neurodegeneration: evolving dimensions and future directions
A Lloret‐Villas, TM Varusai, N Juty… - CPT …, 2017 - Wiley Online Library
Neurodegenerative diseases are a heterogeneous group of disorders that are characterized
by the progressive dysfunction and loss of neurons. Here, we distil and discuss the current …
by the progressive dysfunction and loss of neurons. Here, we distil and discuss the current …
The human body as a super network: Digital methods to analyze the propagation of aging
Biological aging is a complex process involving multiple biological processes. These can be
understood theoretically though considering them as individual networks—eg, epigenetic …
understood theoretically though considering them as individual networks—eg, epigenetic …
Restoring behavior via inverse neurocontroller in a lesioned cortical spiking model driving a virtual arm
Neural stimulation can be used as a tool to elicit natural sensations or behaviors by
modulating neural activity. This can be potentially used to mitigate the damage of brain …
modulating neural activity. This can be potentially used to mitigate the damage of brain …