[HTML][HTML] Neuronal excitation/inhibition imbalance: core element of a translational perspective on Alzheimer pathophysiology

F Maestú, W de Haan, MA Busche, J DeFelipe - Ageing Research Reviews, 2021 - Elsevier
Our incomplete understanding of the link between Alzheimer's Disease pathology and
symptomatology is a crucial obstacle for therapeutic success. Recently, translational studies …

Astrocyte dysfunction in Alzheimer disease

C Acosta, HD Anderson… - Journal of neuroscience …, 2017 - Wiley Online Library
Astrocytes are glial cells that are distributed throughout the central nervous system in an
arrangement optimal for chemical and physical interaction with neuronal synapses and …

Genetic variants in Alzheimer disease—molecular and brain network approaches

C Gaiteri, S Mostafavi, CJ Honey, PL De Jager… - Nature Reviews …, 2016 - nature.com
Genetic studies in late-onset Alzheimer disease (LOAD) are aimed at identifying core
disease mechanisms and providing potential biomarkers and drug candidates to improve …

Bits from brains for biologically inspired computing

M Wibral, JT Lizier, V Priesemann - Frontiers in Robotics and AI, 2015 - frontiersin.org
Inspiration for artificial biologically inspired computing is often drawn from neural systems.
This article shows how to analyze neural systems using information theory with the aim of …

Bridging scales in Alzheimer's disease: biological framework for brain simulation with the virtual brain

L Stefanovski, JM Meier, RK Pai, P Triebkorn… - Frontiers in …, 2021 - frontiersin.org
Despite the acceleration of knowledge and data accumulation in neuroscience over the last
years, the highly prevalent neurodegenerative disease of AD remains a growing problem …

Trigeminal, visceral and vestibular inputs may improve cognitive functions by acting through the locus coeruleus and the ascending reticular activating system: a new …

V De Cicco, MP Tramonti Fantozzi, E Cataldo… - Frontiers in …, 2018 - frontiersin.org
It is known that sensory signals sustain the background discharge of the ascending reticular
activating system (ARAS) which includes the noradrenergic locus coeruleus (LC) neurons …

Tau and amyloid-related pathologies in the entorhinal cortex have divergent effects in the hippocampal circuit

SL Angulo, R Orman, SA Neymotin, L Liu… - Neurobiology of …, 2017 - Elsevier
The entorhinal cortex (EC) is affected early in Alzheimer's disease, an illness defined by a co-
occurrence of tau and amyloid-related pathologies. How the co-occurrence of these …

The impact of mathematical modeling in understanding the mechanisms underlying neurodegeneration: evolving dimensions and future directions

A Lloret‐Villas, TM Varusai, N Juty… - CPT …, 2017 - Wiley Online Library
Neurodegenerative diseases are a heterogeneous group of disorders that are characterized
by the progressive dysfunction and loss of neurons. Here, we distil and discuss the current …

The human body as a super network: Digital methods to analyze the propagation of aging

HJ Whitwell, MG Bacalini, O Blyuss, S Chen… - Frontiers in aging …, 2020 - frontiersin.org
Biological aging is a complex process involving multiple biological processes. These can be
understood theoretically though considering them as individual networks—eg, epigenetic …

Restoring behavior via inverse neurocontroller in a lesioned cortical spiking model driving a virtual arm

S Dura-Bernal, K Li, SA Neymotin, JT Francis… - Frontiers in …, 2016 - frontiersin.org
Neural stimulation can be used as a tool to elicit natural sensations or behaviors by
modulating neural activity. This can be potentially used to mitigate the damage of brain …