The expanding role of pyridine and dihydropyridine scaffolds in drug design
Y Ling, ZY Hao, D Liang, CL Zhang… - Drug design …, 2021 - Taylor & Francis
Pyridine-based ring systems are one of the most extensively used heterocycles in the field of
drug design, primarily due to their profound effect on pharmacological activity, which has led …
drug design, primarily due to their profound effect on pharmacological activity, which has led …
1, 4-Dihydropyridine: Synthetic advances, medicinal and insecticidal properties
A Parthiban, P Makam - RSC advances, 2022 - pubs.rsc.org
1, 4-Dihydropyridine (1, 4-DHP) is one of the foremost notable organic scaffolds with diverse
pharmaceutical applications. This study will highlight recent accomplishments in the …
pharmaceutical applications. This study will highlight recent accomplishments in the …
A century-old one-pot multicomponent Biginelli reaction products still finds a niche in drug discoveries: Synthesis, mechanistic studies and diverse biological activities …
S Faizan, TF Roohi, RM Raju, Y Sivamani… - Journal of Molecular …, 2023 - Elsevier
One of the largest classes of organic molecules are dihydropyrimidines and its derivatives.
They are widely used in a variety of pharmacological and industrial applications. Their …
They are widely used in a variety of pharmacological and industrial applications. Their …
Substrate-Controlled Three-Component Synthesis of Diverse Fused Heterocycles
AA Peshkov, D Gapanenok, A Puzyk… - The Journal of …, 2023 - ACS Publications
A chemoselective strategy toward a variety of fused heterocyclic scaffolds relying on a three-
component condensation of heterocyclic ketene aminals (HKAs) or corresponding …
component condensation of heterocyclic ketene aminals (HKAs) or corresponding …
L-Proline catalyzed one-pot three-component synthesis and evaluation for biological activities of tetrahydrobenzo [b] pyran: Evaluation by green chemistry metrics
A series of tetrahydrobenzo [b] pyrans derivatives were synthesized with substituted
pyrazole carbaldehydes, malononitrile and dimedone by ecofriendly L-proline catalyst in …
pyrazole carbaldehydes, malononitrile and dimedone by ecofriendly L-proline catalyst in …
Synthesis, characterization and molecular docking study of novel 1, 4-dihydropyridine derivatives as antimicrobial and anticancer agents
F Gandomi, KA Dilmaghani, B Massoumi… - Russian Journal of …, 2023 - Springer
In the present study, a new series of 1, 4-dihydropyridine-2-mercapto-quinazolinone hybrids
(VIIa–VIIf) were synthesized by using the nucleophilic substitution reaction of 2-mercapto-3 …
(VIIa–VIIf) were synthesized by using the nucleophilic substitution reaction of 2-mercapto-3 …
Recent advances in the chemistry of two-carbon nitro-containing synthetic equivalents
DN Lyapustin, VV Fedotov, EN Ulomsky… - Uspehi …, 2023 - journals.rcsi.science
To date, nitro-containing compounds form one of the most important classes of organic
compounds. The chemistry of these molecules attracts attention primarily due to their use as …
compounds. The chemistry of these molecules attracts attention primarily due to their use as …
A Review on Synthesis and Biological Potential of Dihydropyridines
S Pathak, S Jain, A Pratap - Letters in Drug Design & Discovery, 2024 - ingentaconnect.com
Dihydropyridine is an outstanding heterocyclic compound with a wide range of
pharmacological potential, including antimicrobial, antioxidant, antitubercular …
pharmacological potential, including antimicrobial, antioxidant, antitubercular …
Design, Synthesis and In‐Silico Studies of Piperidine‐Dihydropyridine Hybrids as Anticancer Agents
In this study, we designed, synthesized and characterized a novel series of piperidine‐
dihydropyridine hybrid compounds and characterized them by 1H‐NMR, 13C NMR, mass …
dihydropyridine hybrid compounds and characterized them by 1H‐NMR, 13C NMR, mass …
One-pot Synthesis of dihydropyridine carboxylic acids via functionalization of 3-((trimethylsilyl) ethynyl) pyridines and an unusual hydration of alkynes: Molecular …
R Ballinas-Indilí, O Gómez-García, E Treviño-Crespo… - Tetrahedron, 2021 - Elsevier
Abstract Activation of 3-((trimethylsilyl) ethynyl) pyridine with triflic anhydride followed by
nucleophilic addition of bis (trimethylsili) ketene acetals and a unusual alkyne hydration …
nucleophilic addition of bis (trimethylsili) ketene acetals and a unusual alkyne hydration …