According to present concepts, innate immunity is regulated by receptors that determine
danger levels by responding to molecules that are associated with infection or cellular …

Oncogenic transformation in human and experimental animals is not necessarily followed by
the appearance of a tumor mass. The immune system of the host can recognize tumor …

MHC class I plays a critical role in the immune defense against viruses and tumors by
presenting antigens to CD8 T cells. An NLR protein, class II transactivator (CIITA), is a key …

The maternal immune system plays a critical role in the establishment, maintenance, and
completion of a healthy pregnancy. However, the specific mechanisms utilized to achieve …

Natural killer cells express inhibitory receptors specific for MHC class I proteins and
stimulatory receptors with diverse specificities. The MHC-specific receptors discriminate …

Major histocompatibility complex class I (MHCI) and class II (MHCII) molecules display
peptides on antigen-presenting cell surfaces for subsequent T-cell recognition. Within the …

The activation NKG2D receptor has been shown to play an important role in the control of
experimental tumor growth and metastases expressing ligands for NKG2D; however, a …

The intestinal epithelium is a critical interface between the organism and its environment.
The cell polarity and structural properties of the enterocytes, limiting the amount of antigen …

The expression of HLA‐G at the fetal‐maternal interface during pregnancy and in
transplanted tissue makes this a key molecule in the acceptance of a semiallogeneic fetus …

The mechanisms by which gut-associated lymphoid tissue (GALT) maintains a balance
between oral tolerance and active immune response in the face of exposure to high antigen …