Animal models of drug relapse and craving: from drug priming-induced reinstatement to incubation of craving after voluntary abstinence
High rates of relapse to drug use during abstinence is a defining feature of drug addiction. In
abstinent drug users, drug relapse is often precipitated by acute exposure to the self …
abstinent drug users, drug relapse is often precipitated by acute exposure to the self …
Drug wanting: behavioral sensitization and relapse to drug-seeking behavior
JD Steketee, PW Kalivas - Pharmacological reviews, 2011 - ASPET
Repeated exposure to drugs of abuse enhances the motor-stimulant response to these
drugs, a phenomenon termed behavioral sensitization. Animals that are extinguished from …
drugs, a phenomenon termed behavioral sensitization. Animals that are extinguished from …
Review on CPP: Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade
TM Tzschentke - Addiction biology, 2007 - Wiley Online Library
Conditioned place preference (CPP) continues to be one of the most popular models to
study the motivational effects of drugs and non‐drug treatments in experimental animals …
study the motivational effects of drugs and non‐drug treatments in experimental animals …
Neurobiology of relapse to heroin and cocaine seeking: a review
The objective of this article is to review data from studies that used a reinstatement model in
rats to elucidate the neural mechanisms underlying relapse to heroin and cocaine seeking …
rats to elucidate the neural mechanisms underlying relapse to heroin and cocaine seeking …
Drug-induced conditioned place preference and aversion in mice
CL Cunningham, CM Gremel, PA Groblewski - Nature protocols, 2006 - nature.com
This protocol describes the equipment and methods used to establish conditioned place
preference (CPP) or aversion (CPA). Place conditioning is a form of Pavlovian conditioning …
preference (CPP) or aversion (CPA). Place conditioning is a form of Pavlovian conditioning …
[HTML][HTML] Sugar addiction: the state of the science
Purpose As obesity rates continue to climb, the notion that overconsumption reflects an
underlying 'food addiction'(FA) has become increasingly influential. An increasingly popular …
underlying 'food addiction'(FA) has become increasingly influential. An increasingly popular …
Neurobiological mechanisms of the reinstatement of drug-conditioned place preference
MA Aguilar, M Rodríguez-Arias, J Miñarro - Brain research reviews, 2009 - Elsevier
Drug addiction is a chronic disorder characterized by a high rate of relapse following
detoxification. There are two main versions of the reinstatement model that are employed to …
detoxification. There are two main versions of the reinstatement model that are employed to …
Effect of environmental stressors on opiate and psychostimulant reinforcement, reinstatement and discrimination in rats: a review
Studies in humans suggest that exposure to life stressors is correlated with compulsive drug
abuse and relapse to drugs during periods of abstinence. The behavioral and …
abuse and relapse to drugs during periods of abstinence. The behavioral and …
Neurobiology of relapse to heroin and cocaine seeking: an update and clinical implications
JM Bossert, UE Ghitza, L Lu, DH Epstein… - European journal of …, 2005 - Elsevier
The central problem in the treatment of cocaine and heroin addiction is high rates of relapse
to drug use after periods of forced or self-imposed abstinence. Relapse can be modeled in …
to drug use after periods of forced or self-imposed abstinence. Relapse can be modeled in …
Epigenetic mechanisms in drug relapse
A growing body of evidence from the past 15 years implicates epigenetic mechanisms in the
behavioral effects of addictive drugs. The main focus of these studies has been epigenetic …
behavioral effects of addictive drugs. The main focus of these studies has been epigenetic …