High rates of relapse to drug use during abstinence is a defining feature of drug addiction. In
abstinent drug users, drug relapse is often precipitated by acute exposure to the self …

Repeated exposure to drugs of abuse enhances the motor-stimulant response to these
drugs, a phenomenon termed behavioral sensitization. Animals that are extinguished from …

Conditioned place preference (CPP) continues to be one of the most popular models to
study the motivational effects of drugs and non‐drug treatments in experimental animals …

The objective of this article is to review data from studies that used a reinstatement model in
rats to elucidate the neural mechanisms underlying relapse to heroin and cocaine seeking …

This protocol describes the equipment and methods used to establish conditioned place
preference (CPP) or aversion (CPA). Place conditioning is a form of Pavlovian conditioning …

Purpose As obesity rates continue to climb, the notion that overconsumption reflects an
underlying 'food addiction'(FA) has become increasingly influential. An increasingly popular …

Drug addiction is a chronic disorder characterized by a high rate of relapse following
detoxification. There are two main versions of the reinstatement model that are employed to …

Studies in humans suggest that exposure to life stressors is correlated with compulsive drug
abuse and relapse to drugs during periods of abstinence. The behavioral and …

The central problem in the treatment of cocaine and heroin addiction is high rates of relapse
to drug use after periods of forced or self-imposed abstinence. Relapse can be modeled in …

A growing body of evidence from the past 15 years implicates epigenetic mechanisms in the
behavioral effects of addictive drugs. The main focus of these studies has been epigenetic …