Alzheimer's disease treatment: the search for a breakthrough

AB Reiss, D Muhieddine, B Jacob, M Mesbah… - Medicina, 2023 - mdpi.com
As the search for modalities to cure Alzheimer's disease (AD) has made slow progress,
research has now turned to innovative pathways involving neural and peripheral …

[HTML][HTML] Aging and cognitive resilience: Molecular mechanisms as new potential therapeutic targets

A Cordeiro, C Gomes, J Bicker, A Fortuna - Drug Discovery Today, 2024 - Elsevier
As the global population ages, the need to prolong lifespan and healthspan becomes
increasingly imperative. Understanding the molecular determinants underlying cognitive …

Effects of cognitive and stress management training in middle-aged and older industrial workers in different socioeconomic settings: a randomized controlled study

PD Gajewski, C Stahn, J Zülch, E Wascher… - Frontiers in …, 2023 - frontiersin.org
Introduction The demographic change requires longer working lifetime. However, fear of job
loss may lead to chronic stress whereas aging and unchallenging work may accelerate …

Trajectories of Occupational Cognitive Demands and Risk of Mild Cognitive Impairment and Dementia in Later Life: The HUNT4 70+ Study

TH Edwin, AK Håberg, E Zotcheva, B Bratsberg… - Neurology, 2024 - AAN Enterprises
Background and Objectives The cognitive reserve hypothesis posits that cognitively
stimulating work delays the onset of mild cognitive impairment (MCI) and dementia …

Identifying longitudinal cognitive resilience from cross-sectional amyloid, tau, and neurodegeneration

R Boyle, DL Townsend, HM Klinger… - Alzheimer's Research & …, 2024 - Springer
Abstract Background Leveraging Alzheimer's disease (AD) imaging biomarkers and
longitudinal cognitive data may allow us to establish evidence of cognitive resilience (CR) to …

GBA moderates cognitive reserve's effect on cognitive function in patients with Parkinson's disease

CW Chang, CH Tan, WP Hong, RL Yu - Journal of Neurology, 2024 - Springer
Background Cognitive reserve (CR) involves an individual's ability to maintain cognitive
vitality over their lifespan. Glucocerebrosidase (GBA) gene mutations contribute to additional …

Estimating Gender Differences in the Association between Cognitive Resilience and Mild Cognitive Impairment Incidence

Y Leung, R Eramudugolla, N Cherbuin, R Peters… - Gerontology, 2024 - karger.com
Introduction: Recent evidence suggests that the influence of verbal intelligence and
education on the onset of subjective cognitive decline may be modulated by gender, where …

Estimating gender differences in the association between cognitive resilience and MCI incidence

Y Leung, R Eramudugolla, N Cherbuin, R Peters… - Gerontology, 2024 - karger.com
Introduction: Recent evidence suggests that the influence of verbal intelligence and
education on the onset of subjective cognitive decline may be modulated by gender, where …

Computerized Cognitive Training in the Older Workforce: Effects on Cognition, Life Satisfaction, and Productivity.

Z Milič Kavčič, V Kavcic, B Giordani… - … Sciences (2076-3417 …, 2024 - search.ebscohost.com
Background: The accelerated aging of the world's population will lead to an increase in the
number of older people in the workforce. Computerized Cognitive Training (CCT) is effective …

Computerized Cognitive Training in the Older Workforce: Effects on Cognition, Life Satisfaction, and Productivity

ZM Kavčič, V Kavcic, B Giordani, U Marusic - 2024 - preprints.org
Background: The accelerated ageing of the world's population will lead to an increase in the
number of older persons in the workforce. Computerized Cognitive Training (CCT) is …