Academic research plays a key role in identifying new drug targets, including understanding
target biology and links between targets and disease states. To lead to new drugs, however …

The second messenger molecule cyclic di-AMP (c-di-AMP) is formed by many bacteria and
archaea. In many species that produce c-di-AMP, this second messenger is essential for …

Many bacterial species are represented by a pan-genome, whose genetic repertoire far
outstrips that of any single bacterial genome. Here we investigate how a bacterial pan …

Forward genetic screens across hundreds of cancer cell lines have started to define the
genetic dependencies of proliferating human cells and how these vary by genotype and …

Gene expression is known to vary among individuals, and this variability can impact the
phenotypic diversity observed in natural populations. While the transcriptome and proteome …

Highlights•The identification of novel drug targets is a key step in drug innovation.•Essential
genes are vital for organism survival and are promising drug targets.•We describe in detail …

Recent noteworthy advances in developing high‐performing microbial and mammalian
strains have enabled the sustainable production of bio‐economically valuable substances …

Cisplatin (CP), a chemotherapy drug commonly used in cancers treatment, causes serious
reproductive toxicity. With younger cancer patients and increasing survival rates, it is …

Genome-scale metabolic models are powerful tools for understanding cellular physiology.
Flux balance analysis (FBA), in particular, is an optimization-based approach widely …

Klebsiella pneumoniae is a ubiquitous human pathogen, and its clinical treatment faces two
major challenges: multidrug resistance and the pathogenesis of hypervirulent K …