We review progress towards greater mechanistic understanding and clinical translation of a
strategy to improve respiratory and non-respiratory motor function in people with …

Key points Ascent to high altitude imposes an acid‐base challenge in which renal
compensation is integral for maintaining pH homeostasis, facilitating acclimatization and …

The assessment of resting perfusion measures (mean transit time, cerebral blood flow, and
cerebral blood volume) with magnetic resonance imaging currently requires the presence of …

This pre-eminent work has developed over six editions in response to man's attempts to
climb higher and higher unaided, and to spend more time at altitude for both work and …

Background Pulmonary hypertension (PH) patients show, during exercise, an excessive
increase in ventilation (VE) compared to carbon dioxide output (VCO 2), determining a high …

The hypoxic ventilatory response (HVR) is the increase in breathing in response to reduced
arterial oxygen pressure. Over several decades, studies have revealed substantial …

New Findings What is the central question of this study? We investigated the interaction
between central and peripheral respiratory chemoreceptors in healthy, awake human …

Chemosensory systems (olfaction, taste, trigeminus nerve, solitary chemoreceptor cells,
neuroendocrine pulmonary cells, and carotid body, etc.) detect molecules outside or inside …

How central and peripheral chemoreceptor drives to breathe interact in humans remains
contentious. We measured the peripheral chemoreflex sensitivity to hypoxia (PChS) at …

High altitude (HA) ascent imposes systemic hypoxia and associated risk of acute mountain
sickness. Acute hypoxia elicits a hypoxic ventilatory response (HVR), which is augmented …