Obstructive Sleep Apnea-Associated Intermittent Hypoxia-Induced Immune Responses in Males, Pregnancies, and Offspring
Obstructive sleep apnea (OSA), a respiratory sleep disorder associated with cardiovascular
diseases, is more prevalent in men. However, OSA occurrence in pregnant women rises to a …
diseases, is more prevalent in men. However, OSA occurrence in pregnant women rises to a …
Pulmonary hypertension: pathophysiology beyond the lung
AC Oliveira, EM Richards, MK Raizada - Pharmacological research, 2020 - Elsevier
Pulmonary hypertension (PH) is classically considered a disease of pulmonary vasculature
which has been the predominant target for drug development and PH therapy. Despite …
which has been the predominant target for drug development and PH therapy. Despite …
A feature of maternal sleep apnea during gestation causes autism-relevant neuronal and behavioral phenotypes in offspring
AM Vanderplow, BA Kermath, CR Bernhardt… - PLoS …, 2022 - journals.plos.org
Mounting epidemiologic and scientific evidence indicates that many psychiatric disorders
originate from a complex interplay between genetics and early life experiences, particularly …
originate from a complex interplay between genetics and early life experiences, particularly …
ACE2 overexpression in corticotropin-releasing-hormone cells offers protection against pulmonary hypertension
AC Oliveira, MM Karas, M Alves, J He… - Frontiers in …, 2023 - frontiersin.org
Background Pulmonary hypertension (PH), characterized by elevated pulmonary pressure
and right heart failure, is a systemic disease involving inappropriate sympathetic activation …
and right heart failure, is a systemic disease involving inappropriate sympathetic activation …
Spermidine prevents heart injury in neonatal rats exposed to intrauterine hypoxia by inhibiting oxidative stress and mitochondrial fragmentation
N Chai, H Zhang, L Li, X Yu, Y Liu, Y Lin… - Oxidative medicine …, 2019 - Wiley Online Library
Intrauterine hypoxia (IUH) is a common intrauterine dysplasia that can cause programming
of the offspring cardiovascular system. In this study, we hypothesized that placental …
of the offspring cardiovascular system. In this study, we hypothesized that placental …
Pulmonary arterial hypertension-associated changes in gut pathology and microbiota
Emerging evidence implicates an interplay among multiple organs such as brain,
vasculature, gut and lung in the development of established pulmonary arterial hypertension …
vasculature, gut and lung in the development of established pulmonary arterial hypertension …
[HTML][HTML] Gestational intermittent hypoxia induces sex-specific impairment in endothelial mechanisms and sex steroid hormone levels in male rat offspring
Obstructive sleep apnea (OSA) is highly prevalent during gestation and is linked with
adverse fetal outcomes. We examined whether gestational intermittent hypoxia (GIH), the …
adverse fetal outcomes. We examined whether gestational intermittent hypoxia (GIH), the …
Alzheimer's disease, sleep disordered breathing, and microglia: puzzling out a common link
TK Ulland, AC Ewald, AO Knutson, KM Marino… - Cells, 2021 - mdpi.com
Sleep Disordered Breathing (SDB) and Alzheimer's Disease (AD) are strongly associated
clinically, but it is unknown if they are mechanistically associated. Here, we review data …
clinically, but it is unknown if they are mechanistically associated. Here, we review data …
Impact of inflammation on developing respiratory control networks: rhythm generation, chemoreception and plasticity
SA Beyeler, MR Hodges, AG Huxtable - Respiratory physiology & …, 2020 - Elsevier
The respiratory control network in the central nervous system undergoes critical
developmental events early in life to ensure adequate breathing at birth. There are at least …
developmental events early in life to ensure adequate breathing at birth. There are at least …
[PDF][PDF] Sex-specific effects of stress on respiratory control: plasticity, adaptation, and dysfunction
L Tenorio-Lopes, R Kinkead - Compr. Physiol, 2021 - researchgate.net
As our understanding of respiratory control evolves, we appreciate how the basic
neurobiological principles of plasticity discovered in other systems shape the development …
neurobiological principles of plasticity discovered in other systems shape the development …