Obstructive Sleep Apnea-Associated Intermittent Hypoxia-Induced Immune Responses in Males, Pregnancies, and Offspring

R Song, TL Baker, JJ Watters, S Kumar - International Journal of …, 2024 - mdpi.com
Obstructive sleep apnea (OSA), a respiratory sleep disorder associated with cardiovascular
diseases, is more prevalent in men. However, OSA occurrence in pregnant women rises to a …

Pulmonary hypertension: pathophysiology beyond the lung

AC Oliveira, EM Richards, MK Raizada - Pharmacological research, 2020 - Elsevier
Pulmonary hypertension (PH) is classically considered a disease of pulmonary vasculature
which has been the predominant target for drug development and PH therapy. Despite …

A feature of maternal sleep apnea during gestation causes autism-relevant neuronal and behavioral phenotypes in offspring

AM Vanderplow, BA Kermath, CR Bernhardt… - PLoS …, 2022 - journals.plos.org
Mounting epidemiologic and scientific evidence indicates that many psychiatric disorders
originate from a complex interplay between genetics and early life experiences, particularly …

ACE2 overexpression in corticotropin-releasing-hormone cells offers protection against pulmonary hypertension

AC Oliveira, MM Karas, M Alves, J He… - Frontiers in …, 2023 - frontiersin.org
Background Pulmonary hypertension (PH), characterized by elevated pulmonary pressure
and right heart failure, is a systemic disease involving inappropriate sympathetic activation …

Spermidine prevents heart injury in neonatal rats exposed to intrauterine hypoxia by inhibiting oxidative stress and mitochondrial fragmentation

N Chai, H Zhang, L Li, X Yu, Y Liu, Y Lin… - Oxidative medicine …, 2019 - Wiley Online Library
Intrauterine hypoxia (IUH) is a common intrauterine dysplasia that can cause programming
of the offspring cardiovascular system. In this study, we hypothesized that placental …

Pulmonary arterial hypertension-associated changes in gut pathology and microbiota

RK Sharma, AC Oliveira, T Yang, S Kim… - ERJ Open …, 2020 - Eur Respiratory Soc
Emerging evidence implicates an interplay among multiple organs such as brain,
vasculature, gut and lung in the development of established pulmonary arterial hypertension …

[HTML][HTML] Gestational intermittent hypoxia induces sex-specific impairment in endothelial mechanisms and sex steroid hormone levels in male rat offspring

R Song, JS Mishra, SV Dangudubiyyam… - Reproductive …, 2022 - Springer
Obstructive sleep apnea (OSA) is highly prevalent during gestation and is linked with
adverse fetal outcomes. We examined whether gestational intermittent hypoxia (GIH), the …

Alzheimer's disease, sleep disordered breathing, and microglia: puzzling out a common link

TK Ulland, AC Ewald, AO Knutson, KM Marino… - Cells, 2021 - mdpi.com
Sleep Disordered Breathing (SDB) and Alzheimer's Disease (AD) are strongly associated
clinically, but it is unknown if they are mechanistically associated. Here, we review data …

Impact of inflammation on developing respiratory control networks: rhythm generation, chemoreception and plasticity

SA Beyeler, MR Hodges, AG Huxtable - Respiratory physiology & …, 2020 - Elsevier
The respiratory control network in the central nervous system undergoes critical
developmental events early in life to ensure adequate breathing at birth. There are at least …

[PDF][PDF] Sex-specific effects of stress on respiratory control: plasticity, adaptation, and dysfunction

L Tenorio-Lopes, R Kinkead - Compr. Physiol, 2021 - researchgate.net
As our understanding of respiratory control evolves, we appreciate how the basic
neurobiological principles of plasticity discovered in other systems shape the development …