Spermatogenesis and folliculogenesis involve cell–cell interactions and gene expression
orchestrated by luteinizing hormone (LH) and follicle-stimulating hormone (FSH). FSH …

Spermatogenesis is a concerted sequence of events during maturation of spermatogonia
into spermatozoa. The process involves differential gene-expression and cell-cell interplay …

Primary ovarian insufficiency (POI) affects∼ 1% of women before 40 years of age. The
recent leap in genetic knowledge obtained by next generation sequencing (NGS) together …

NOBOX (newborn ovary homeobox gene) is an oocyte-specific homeobox gene that plays a
critical role in early folliculogenesis and represents a candidate gene for nonsyndromic …

The FSH receptor shows three single nucleotide polymorphisms (SNPs), one in the
promoter and two in exon 10. In addition, the FSH receptor mRNA undergoes extensive …

G protein-coupled receptors (GPCR) comprise the largest family of drug targets. This is not
surprising as many signaling systems rely on this class of receptor to convert external and …

Testicular growth during puberty is rapid, and mostly due to germ cell expansion and growth
in seminiferous tubule diameter triggered by androgens. Pre-treatment with FSH before the …

Inactivating mutations of the FSH receptor (FSHR) are known to cause ovarian failure with
amenorrhea and infertility in women. The first mutation identified in the FSHR gene was a …

Inactivating mutations of the FSH receptor have been described in rare cases of premature
ovarian failure. Only one mutation was associated with a complete phenotype, including …

This short review provides an update on the new information that has become available in
the recent years about mutations and polymorphisms in the genes for gonadotropins and …