Sublethal hypoxic or ischemic events can improve the tolerance of tissues, organs, and even
organisms from subsequent lethal injury caused by hypoxia or ischemia. This phenomenon …

Cerebral ischemia is caused by arterial occlusion due to a thrombus or an embolus. Such
occlusion induces multiple and concomitant pathophysiological processes that involve …

Background and Purpose—The search for effective neuroprotectants remains frustrating,
particularly with regard to specific pharmaceuticals. However, laboratory studies have …

Central nervous system diseases are among the most disabling in the world.
Neuroprotection and brain recovery from either acute or chronic neurodegeneration still …

Background and purpose A major gap in the field of ischemic preconditioning (IPC) is
whether or not long-lasting neuroprotection can be achieved. Moreover, the specific …

Stroke is one of the leading causes of morbidity and mortality worldwide, and it is increasing
in prevalence. The limited therapeutic window and potential severe side effects prevent the …

Objective: To determine clinical and pharmacologic factors that could influence the initial
severity and short-term outcome of cerebral ischemia. Methods: In a cross-sectional hospital …

Ischemic conditioning is a form of endogenous protection induced by transient, subcritical
ischemia in a tissue. Organs with high sensitivity to ischemia, such as the heart, the brain …

Ischemic stroke is a major cause of death worldwide, and current therapeutic options are
very limited. Preconditioning with an ischemic or hypoxic insult is beneficial in experimental …

Ischemic tolerance defines transient resistance to lethal ischemia gained by a prior sublethal
noxious stimulus (ie, preconditioning). This adaptive response is thought to be an …