Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome
R Lv, X Liu, Y Zhang, N Dong, X Wang, Y He… - Signal transduction and …, 2023 - nature.com
Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in sleep in
which the airways narrow or collapse during sleep, causing obstructive sleep apnea. The …
which the airways narrow or collapse during sleep, causing obstructive sleep apnea. The …
DNA methylation markers in obesity, metabolic syndrome, and weight loss
M Samblas, FI Milagro, A Martínez - Epigenetics, 2019 - Taylor & Francis
The fact that not all individuals exposed to the same environmental risk factors develop
obesity supports the hypothesis of the existence of underlying genetic and epigenetic …
obesity supports the hypothesis of the existence of underlying genetic and epigenetic …
A comparison of pathophysiology in humans and rodent models of subarachnoid hemorrhage
JL Leclerc, JM Garcia, MA Diller… - Frontiers in molecular …, 2018 - frontiersin.org
Non-traumatic subarachnoid hemorrhage (SAH) affects an estimated 30,000 people each
year in the United States, with an overall mortality of~ 30%. Most cases of SAH result from a …
year in the United States, with an overall mortality of~ 30%. Most cases of SAH result from a …
Advances in molecular pathology of obstructive sleep apnea
M Zhang, Y Lu, L Sheng, X Han, L Yu, W Zhang, S Liu… - Molecules, 2022 - mdpi.com
Obstructive sleep apnea (OSA) is a common syndrome that features a complex etiology and
set of mechanisms. Here we summarized the molecular pathogenesis of OSA, especially the …
set of mechanisms. Here we summarized the molecular pathogenesis of OSA, especially the …
Early postnatal exposure to intermittent hypoxia in rodents is proinflammatory, impairs white matter integrity, and alters brain metabolism
RA Darnall, X Chen, KV Nemani, CM Sirieix, B Gimi… - Pediatric …, 2017 - nature.com
Background Preterm infants are frequently exposed to intermittent hypoxia (IH) associated
with apnea and periodic breathing that may result in inflammation and brain injury that later …
with apnea and periodic breathing that may result in inflammation and brain injury that later …
Epigenetics: a potential mechanism involved in the pathogenesis of various adverse consequences of obstructive sleep apnea
YC Chen, PY Hsu, CC Hsiao, MC Lin - International journal of molecular …, 2019 - mdpi.com
Epigenetics is defined as the heritable phenotypic changes which do not involve alterations
in the DNA sequence, including histone modifications, non-coding RNAs, and DNA …
in the DNA sequence, including histone modifications, non-coding RNAs, and DNA …
Circulating exosomes in obstructive sleep apnea as phenotypic biomarkers and mechanistic messengers of end-organ morbidity
A Khalyfa, L Kheirandish-Gozal, D Gozal - Respiratory physiology & …, 2018 - Elsevier
Obstructive sleep apnea (OSA), the most severe form of sleep disordered breathing, is
characterized by intermittent hypoxia during sleep (IH), sleep fragmentation, and episodic …
characterized by intermittent hypoxia during sleep (IH), sleep fragmentation, and episodic …
Effects of early-and mid-life stress on DNA methylation of genes associated with subclinical cardiovascular disease and cognitive impairment: a systematic review
EM Vidrascu, AC Bashore, TD Howard, JB Moore - BMC medical genetics, 2019 - Springer
Background Traditional and novel risk factors cannot sufficiently explain the differential
susceptibility to cardiovascular disease (CVD). Epigenetics may serve to partially explain …
susceptibility to cardiovascular disease (CVD). Epigenetics may serve to partially explain …
Intermittent hypoxia in utero damages postnatal growth and cardiovascular function in rats
L Chen, ZH Zadi, J Zhang… - Journal of Applied …, 2018 - journals.physiology.org
Obstructive sleep apnea (OSA) is common in pregnancy and may compromise fetal and
even postnatal development. We developed an animal model to determine if maternal OSA …
even postnatal development. We developed an animal model to determine if maternal OSA …
The epigenetic machinery in vascular dysfunction and hypertension
Hypertension (HT) is among the major components of the metabolic syndrome, ie, obesity,
dyslipidemia, and hyperglycemia/insulin resistance. It represents a significant health …
dyslipidemia, and hyperglycemia/insulin resistance. It represents a significant health …