Update on Chlamydia trachomatis vaccinology

LM de la Maza, G Zhong… - Clinical and Vaccine …, 2017 - Am Soc Microbiol
Attempts to produce a vaccine to protect against Chlamydia trachomatis-induced trachoma
were initiated more than 100 years ago and continued for several decades. Using whole …

Chlamydia trachomatis vaccines for genital infections: where are we and how far is there to go?

LM de la Maza, TL Darville, S Pal - Expert review of vaccines, 2021 - Taylor & Francis
Introduction Chlamydia trachomatis is the most common sexually transmitted bacterial
pathogen in the world. Antibiotic treatment does not prevent against reinfection and a …

[HTML][HTML] Chlamydia trachomatis and the HLA involvement in the development of infection and disease: a narrative review

ML Pintea-Trifu, Ş Bâlici, CV Siserman… - Medicine and …, 2023 - ncbi.nlm.nih.gov
Methods Pubmed was researched using key terms. Out of the 198 results found, we
analyzed articles of all types which describe how the MHC, through HLA alleles, participates …

CD4+ T-cell epitope prediction using antigen processing constraints

RR Mettu, T Charles, SJ Landry - Journal of immunological methods, 2016 - Elsevier
T-cell CD4+ epitopes are important targets of immunity against infectious diseases and
cancer. State-of-the-art methods for MHC class II epitope prediction rely on supervised …

Transcervical inoculation with Chlamydia trachomatis induces infertility in HLA-DR4 transgenic and wild-type mice

S Pal, DF Tifrea, G Zhong, LM de la Maza - Infection and immunity, 2018 - Am Soc Microbiol
Chlamydia trachomatis is the leading cause of infection-induced infertility in women.
Attempts to control this epidemic with screening programs and antibiotic therapy have failed …

Vaccination with the polymorphic membrane protein A reduces Chlamydia muridarum induced genital tract pathology

T Müller, E Becker, S Stallmann, A Waldhuber… - Vaccine, 2017 - Elsevier
Chlamydia trachomatis serovars DK are one of the most frequent causes of sexually
transmitted infections of the female genital tract, with possible complications such as …

Identifying HLA DRB1-DQB1 alleles associated with Chlamydia trachomatis infection and in silico prediction of potentially-related peptides

L Pedraza, M Camargo, DA Moreno-Pérez… - Scientific Reports, 2021 - nature.com
Abstract HLA class II (HLA-II) genes' polymorphism influences the immune response to
Chlamydia trachomatis (Ct), it is considered a sexually transmitted infection. However …

Development and Evaluation of an Immunoinformatics-Based Multi-Peptide Vaccine against Acinetobacter baumannii Infection

S Jeffreys, MP Tompkins, J Aki, SB Papp, JP Chambers… - Vaccines, 2024 - mdpi.com
Multi-drug-resistant (MDR) Acinetobacter baumannii is an opportunistic pathogen
associated with hospital-acquired infections. Due to its environmental persistence, virulence …

Protective Anti-Chlamydial Vaccine Regimen-Induced CD4+ T cell Response Mediates Early Inhibition of Pathogenic CD8+ T cell Response Following Genital …

AK Murthy, E Wright-McAfee, K Warda… - Pathogens and …, 2024 - academic.oup.com
We have demonstrated previously that TNF-α-producing CD8+ T cells mediate chlamydial
pathogenesis, likely in an antigen (Ag)-specific fashion. Here we hypothesize that inhibition …

Immune response characterization and vaccine potential of a recombinant chimera comprising B-cell epitope of Aeromonas hydrophila outer membrane protein C and …

M Sharma, A Dixit - Vaccine, 2016 - Elsevier
Aeromonas hydrophila is one of the most virulent fish pathogens, causing colossal
economic losses to the aquaculture industry annually. The absence of a safe and effective …