Procalcitonin: where are we now?

B Hamade, DT Huang - Critical Care Clinics, 2020 - criticalcare.theclinics.com
Procalcitonin (PCT) is a protein that consists of 116 amino acids and is the peptide precursor
of calcitonin. Calcitonin is initially biosynthesized as PCT, which, under normal conditions, is …

Procalcitonin-guided antibiotic discontinuation and mortality in critically ill adults: a systematic review and meta-analysis

DJ Pepper, J Sun, C Rhee, J Welsh, JH Powers III… - Chest, 2019 - Elsevier
Background Procalcitonin (PCT)-guided antibiotic discontinuation appears to decrease
antibiotic use in critically ill patients, but its impact on survival remains less certain. Methods …

Procalcitonin (PCT)-guided antibiotic stewardship: an international experts consensus on optimized clinical use

P Schuetz, A Beishuizen, M Broyles… - Clinical Chemistry and …, 2019 - degruyter.com
Background Procalcitonin (PCT)-guided antibiotic stewardship (ABS) has been shown to
reduce antibiotics (ABxs), with lower side-effects and an improvement in clinical outcomes …

Management of sepsis and septic shock: what have we learned in the last two decades?

S Kamath, H Hammad Altaq, T Abdo - Microorganisms, 2023 - mdpi.com
Sepsis is a clinical syndrome encompassing physiologic and biological abnormalities
caused by a dysregulated host response to infection. Sepsis progression into septic shock is …

Procalcitonin-guided antibiotic therapy may shorten length of treatment and may improve survival—a systematic review and meta-analysis

M Papp, N Kiss, M Baka, D Trásy, L Zubek, P Fehérvári… - Critical Care, 2023 - Springer
Background Appropriate antibiotic (AB) therapy remains a challenge in the intensive care
unit (ICU). Procalcitonin (PCT)-guided AB stewardship could help optimize AB treatment and …

Procalcitonin for individualizing antibiotic treatment: an update with a focus on COVID-19

S Wolfisberg, C Gregoriano… - Critical reviews in clinical …, 2022 - Taylor & Francis
Procalcitonin (PCT) is useful for differentiating between viral and bacterial infections and for
reducing the unnecessary use of antibiotics. As the rise of antimicrobial resistance reaches …

Antimicrobial stewardship using biomarkers: Accumulating evidence for the critically ill

E Kyriazopoulou, EJ Giamarellos-Bourboulis - Antibiotics, 2022 - mdpi.com
This review aims to summarize current progress in the management of critically ill, using
biomarkers as guidance for antimicrobial treatment with a focus on antimicrobial …

[HTML][HTML] A 2020 review on the role of procalcitonin in different clinical settings: an update conducted with the tools of the evidence based laboratory medicine

AM Azzini, RM Dorizzi, P Sette, M Vecchi… - Annals of …, 2020 - ncbi.nlm.nih.gov
Biomarkers to guide antibiotic treatment decisions have been proposed as an effective way
to enhancing a more appropriate use of antibiotics. As a biomarker, procalcitonin (PCT) has …

Procalcitonin-guided antibiotic therapy algorithms for different types of acute respiratory infections based on previous trials

P Schuetz, R Bolliger, M Merker… - Expert review of anti …, 2018 - Taylor & Francis
Introduction: Although evidence indicates that use of procalcitonin to guide antibiotic
decisions for the treatment of acute respiratory infections (ARI) decreases antibiotic …

A machine learning framework for identifying influenza pneumonia from bacterial pneumonia for medical decision making

Q Zhang, A Huang, L Shao, P Wu, AA Heidari… - Journal of …, 2022 - Elsevier
Accurately identifying viruses from bacteria determine the therapy and outcome of patients
suffering from pneumonia. This study focuses on exploring the capability of machine …