Heparan sulfate (HS) is ubiquitously expressed on cell surfaces and in the extracellular
matrix. HS is a highly negatively charged polysaccharide. Hundreds of proteins have …

Carbohydrates have been shown to play important roles in biological processes. The pace
of development in carbohydrate research is, however, relatively slow due to the problems …

Ultralow molecular weight (ULMW) heparins are sulfated glycans that are clinically used to
treat thrombotic disorders. ULMW heparins range from 1500 to 3000 daltons, corresponding …

Heparin and heparan sulfate glycosaminoglycans are long, linear polysaccharides that are
made up of alternating dissacharide sequences of sulfated uronic acid and amino sugars …

Highlights•Metabolic engineering of heparosan, heparin and heparan sulfate•Chemical and
chemoenzymatic synthesis of low molecular weight heparins•Development of new heparin …

Angiogenesis, the process of formation of new blood vessel from pre-existing ones, is
involved in various intertwined pathological processes including virus infection …

Heparan sulfate is a sulfated glycan that exhibits essential physiological functions.
Interrogation of the specificity of heparan sulfate-mediated activities demands a library of …

Low–molecular weight heparin (LMWH) is used clinically to treat clotting disorders. As an
animal-sourced product, LMWH is a highly heterogeneous mixture, and its anticoagulant …

Although polysaccharides are ubiquitous and the most abundant renewable bio-
components, their studies, covered by the glycochemistry and glycobiology fields, remain a …

Complex carbohydrates (glycans) are major players in all organisms due to their structural,
energy, and communication roles. This last essential role involves interacting and/or …