The miR-200 family of microRNAs: fine tuners of epithelial-mesenchymal transition and circulating cancer biomarkers

I Cavallari, F Ciccarese, E Sharova, L Urso… - Cancers, 2021 - mdpi.com
Simple Summary MicroRNAs (miRNAs) are small RNA molecules that regulate gene
expression by blocking translation or inducing degradation of specific gene transcripts. The …

Crosstalk between peroxisome proliferator-activated receptor gamma and the canonical WNT/β-catenin pathway in chronic inflammation and oxidative stress during …

A Vallée, Y Lecarpentier - Frontiers in immunology, 2018 - frontiersin.org
Inflammation and oxidative stress are common and co-substantial pathological processes
accompanying, promoting, and even initiating numerous cancers. The canonical WNT/β …

Tight junction protein signaling and cancer biology

Z Nehme, N Roehlen, P Dhawan, TF Baumert - Cells, 2023 - mdpi.com
Tight junctions (TJs) are intercellular protein complexes that preserve tissue homeostasis
and integrity through the control of paracellular permeability and cell polarity. Recent …

pH‐responsive PEG‐shedding and Targeting peptide‐modified nanoparticles for dual‐delivery of Irinotecan and microRNA to enhance tumor‐specific therapy

V Juang, CH Chang, CS Wang, HE Wang, YL Lo - Small, 2019 - Wiley Online Library
Irinotecan is one of the main chemotherapeutic agents for colorectal cancer (CRC).
MicroRNA‐200 (miR‐200) has been reported to inhibit metastasis in cancer cells. Herein …

Redox regulation in tumor cell epithelial–mesenchymal transition: Molecular basis and therapeutic strategy

J Jiang, K Wang, Y Chen, H Chen, EC Nice… - … and Targeted Therapy, 2017 - nature.com
Epithelial–mesenchymal transition (EMT) is recognized as a driving force of cancer cell
metastasis and drug resistance, two leading causes of cancer recurrence and cancer …

Long non-coding RNAs as the critical regulators of epithelial mesenchymal transition in colorectal tumor cells: an overview

AA Hamidi, G Khalili-Tanha, Z Nasrpour Navaei… - Cancer cell …, 2022 - Springer
Colorectal cancer (CRC) is the second most common cause of cancer mortality and a major
health challenge worldwide. Despite advances in therapeutic and diagnostic methods, there …

Epithelial-to-mesenchymal transition in tumor progression

E Prieto-García, CV Díaz-García, I García-Ruiz… - Medical Oncology, 2017 - Springer
The epithelial-to-mesenchymal transition (EMT) is a biological process in which a non-motile
epithelial cell changes to a mesenchymal state with invasive capacities. However, the EMT …

Molecular mechanisms of epithelial to mesenchymal transition in tumor metastasis

A Nieszporek, K Skrzypek, G Adamek… - Acta Biochimica …, 2019 - ruj.uj.edu.pl
Epithelial to mesenchymal transition (EMT) is a process where cancer cells lose their
epithelial features, the cytoskeletal architecture is re-organized, the cell shape changes and …

Therapeutic strategies targeting Wnt/β‑catenin signaling for colorectal cancer

Y Ji, J Lv, D Sun, Y Huang - … journal of molecular …, 2022 - spandidos-publications.com
Colorectal cancer (CRC) is one of the most common carcinomas. Although great progress
has been made in recent years, CRC survival remains unsatisfactory due to high metastasis …

Mechanisms of chemopreventive and therapeutic proprieties of ginger extracts in cancer

M Zadorozhna, D Mangieri - International journal of molecular sciences, 2021 - mdpi.com
Ginger (Zingiber officinale Roscoe, family: Zingiberaceae), originating in South-East Asia, is
one of the most used spices and condiments for foods and beverages. It is also used in …