Perturbations in cardiac energy metabolism are major contributors to a number of
cardiovascular pathologies. In addition, comorbidities associated with cardiovascular …

The goal of this review is to present a comprehensive survey of the many intriguing facets of
creatine (Cr) and creatinine metabolism, encompassing the pathways and regulation of Cr …

Abnormalities of cardiac energy metabolism make an important contribution to chronic heart
failure. This review summarizes the main events in cardiac energy metabolism, discusses …

increase in ratio of angiotensin II AT2 to AT1 receptor subtypes). Some of these switches,
such as the increased expression of the slow myosin ATPase isoform-myosin heavy chain …

Swynghedauw, Bernard. Molecular Mechanisms of Myocardial Remodeling. Physiol. Rev.
79: 215–262, 1999.—“Remodeling” implies changes that result in rearrangement of …

Background In patients with heart failure due to dilated cardiomyopathy, cardiac energy
metabolism is impaired, as indicated by a reduction of the myocardial phosphocreatine-to …

Background—Atrial fibrillation (AF) is associated with severe contractile dysfunction and
structural and electrophysiological remodeling. Mechanisms responsible for impaired …

Heart failure (HF) is a syndrome resulting from the inability of the cardiac pump to meet the
energy requirements of the body. Despite intensive work, the pathogenesis of the cardiac …

Myocytes of the failing heart undergo impressive metabolic remodelling. The time line for
changes in the pathways for ATP synthesis in compensated hypertrophy is: flux through the …

The requirement of chemical energy in the form of ATP to support systolic and diastolic work
of the heart is absolute. Because of its central role in cardiac metabolism and performance …