Depending on the definitions used, up to 10% of all live-born neonates are small for
gestational age (SGA). Although the vast majority of these children show catch-up growth by …

The diagnosis of GH deficiency (GHD) in childhood is a multistep process involving clinical
history, examination with detailed auxology, biochemical testing, and pituitary imaging, with …

Isolated growth hormone deficiency is the most common pituitary hormone deficiency and
can result from congenital or acquired causes, although the majority of cases are idiopathic …

Background The treatment of acromegaly resistant to first-generation somatostatin receptor
ligands (SRLs) is often difficult. Pegvisomant and Pasireotide LAR are mostly used in these …

Growth hormone (GH) is widely prescribed for children with short stature across a range of
growth disorders. Recombinant human (rh) insulin‐like growth factor‐1 (rhIGF‐1) therapy is …

Although both growth hormone (GH) and insulin-like growth factor 1 (IGF-1) signaling were
shown to regulate life span in lower organisms, the role of GH signaling in human longevity …

The use of growth hormone (GH) to treat children who have disturbances of growth is
complicated by variability both within and across diagnostic groups, and at the start of and …

Context: The exon-3 deleted GH receptor (GHRd3) polymorphism is associated with an
increased growth response to recombinant human GH (rhGH) therapy in some, but not all …

In the management of ISS auxological, biochemical, psychosocial and ethical elements
have to be considered. In boys with constitutional delay of growth and puberty androgens …

Context: A variant of the human GH receptor (GHR) lacks a 22-amino-acid sequence
derived from exon 3 (d3-GHR). It was reported that pediatric patients, born small for …