Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in
response to various intrinsic and extrinsic stimuli, as well as developmental signals …

The maintenance of genome stability depends on the DNA damage response (DDR), which
is a functional network comprising signal transduction, cell cycle regulation and DNA repair …

Repair of dsDNA breaks requires processing to produce 3′-terminated ssDNA. We
biochemically reconstituted DNA end resection using purified human proteins: Bloom …

The ataxia-telangiectasia mutated (ATM) kinase signals the presence of DNA double-strand
breaks in mammalian cells by phosphorylating proteins that initiate cell-cycle arrest …

Accumulation of repair proteins on damaged chromosomes is required to restore genomic
integrity. However, the mechanisms of protein retention at the most destructive chromosomal …

Aging can be defined as progressive functional decline and increasing mortality over time.
Here, we review evidence linking aging to nuclear DNA lesions: DNA damage accumulates …

DNA double-strand breaks are repaired by different mechanisms, including homologous
recombination and nonhomologous end-joining. DNA-end resection, the first step in …

The repair of DNA double-strand breaks (DSBs) by homologous recombination requires
processing of broken ends. For repair to start, the DSB must first be resected to generate a …

Chromosomal double strand breaks provoke an extensive reaction in neighboring
chromatin, characterized by phosphorylation of histone H2AX on serine 139 of its C-terminal …

In this study, we investigate the interplay between Ku, a central non‐homologous end‐
joining component, and the Mre11–Rad50–Xrs2 (MRX) complex and Sae2, end‐processing …