Molecular Epidemiology, Evolution, and Ecology of Francisella

P Keim, A Johansson… - Annals of the New York …, 2007 - Wiley Online Library
Tularemia is a disease caused by several subspecies of Francisella tularensis, although the
severity of the disease varies greatly from subspecies to subspecies. Currently, there are …

Francisella tularensis: Taxonomy, Genetics, and Immunopathogenesis of a Potential Agent of Biowarfare

MK McLendon, MA Apicella, LAH Allen - Annu. Rev. Microbiol., 2006 - annualreviews.org
Tularemia is a zoonosis of humans caused by infection with the facultative intracellular
bacterium Francisella tularensis. Interest in F. tularensis has increased markedly in the past …

[HTML][HTML] Epidemiologic and molecular analysis of human tularemia, United States, 1964–2004

JE Staples, KA Kubota, LG Chalcraft… - Emerging infectious …, 2006 - ncbi.nlm.nih.gov
Abstract Tularemia in the United States is caused by 2 subspecies of Francisella tularensis,
subspecies tularensis (type A) and subspecies holarctica (type B). We compared clinical and …

[图书][B] Molecular detection of human bacterial pathogens

D Liu - 2011 - books.google.com
As more original molecular protocols and subsequent modifications are described in the
literature, it has become difficult for those not directly involved in the development of these …

Lack of In Vitro and In Vivo Recognition of Francisella tularensis Subspecies Lipopolysaccharide by Toll-Like Receptors

AM Hajjar, MD Harvey, SA Shaffer… - Infection and …, 2006 - Am Soc Microbiol
Francisella tularensis is an intracellular gram-negative bacterium that is highly infectious
and potentially lethal. Several subspecies exist of varying pathogenicity. Infection by only a …

Comparison of Francisella tularensis genomes reveals evolutionary events associated with the emergence of human pathogenic strains

L Rohmer, C Fong, S Abmayr, M Wasnick… - Genome biology, 2007 - Springer
Background Francisella tularensis subspecies tularensis and holarctica are pathogenic to
humans, whereas the two other subspecies, novicida and mediasiatica, rarely cause …

Working toward the Future: Insights into Francisella tularensis Pathogenesis and Vaccine Development

RD Pechous, TR McCarthy… - … and molecular biology …, 2009 - Am Soc Microbiol
Francisella tularensis is a facultative intracellular gram-negative pathogen and the
etiological agent of the zoonotic disease tularemia. Recent advances in the field of …

Molecular Epidemiology of Francisella tularensis in the United States

KJ Kugeler, PS Mead, AM Janusz… - Clinical Infectious …, 2009 - academic.oup.com
Abstract Background. In the United States, tularemia is caused by Francisella tularensis
subsps. tularensis (type A) and holarctica (type B). Molecular subtyping has further divided …

Antivirulence genes: insights into pathogen evolution through gene loss

KA Bliven, AT Maurelli - Infection and immunity, 2012 - Am Soc Microbiol
The emergence of new pathogens and the exploitation of novel pathogenic niches by
bacteria typically require the horizontal transfer of virulence factors and subsequent …

Phylogeography of Francisella tularensis: Global Expansion of a Highly Fit Clone

AJ Vogler, D Birdsell, LB Price, JR Bowers… - Journal of …, 2009 - Am Soc Microbiol
Francisella tularensis contains several highly pathogenic subspecies, including Francisella
tularensis subsp. holarctica, whose distribution is circumpolar in the northern hemisphere …