B. DNA binding properties C. PPAR ligand-binding properties D. Alternative pathways for
PPAR activation E. PPAR-mediated transactivation properties III. Physiological Aspects A …

Maturity-onset diabetes of the young (MODY) is a clinically heterogeneous group of
disorders characterized by nonketotic diabetes mellitus, an autosomal dominant mode of …

Hepatocyte nuclear factor 4α (HNF4α) is essential for liver development and hepatocyte
function. Here, we show that transient inhibition of HNF4α initiates hepatocellular …

The numerous functions of the liver are controlled primarily at the transcriptional level by the
concerted actions of a limited number of hepatocyte-enriched transcription factors …

The three types of peroxisome proliferator-activated receptors (PPAR), termed alpha, delta
(or beta), and gamma, belong to the nuclear receptor superfamily. Although peroxisome …

This review addresses recent developments regarding the peroxisome proliferator activated
receptors (PPARs). We will briefly review the older literature regarding the phenomenon of …

Cholesterol degradation to bile acids in the liver can be initiated by either cholesterol 7a-
hydroxylase (CYP7A1) of the classic (neutral) pathway, or by mitochondrial sterol 27 …

II. Nuclear Receptors: General Concepts A. Anatomy of nuclear receptors B. Mechanisms of
action III. Orphan Nuclear Receptors A. Definition

Dietary fatty acids have a considerable effect on plasma LDL cholesterol (LDL-C)
concentrations and therefore on the risk for coronary heart disease. Numerous studies have …

Steatosis of the liver may arise from a variety of conditions, but the molecular basis for lipid
droplet formation is poorly understood. Although a certain amount of lipid storage may even …