Infections with parasitic helminths cause severe debilitating and sometimes lethal diseases
in humans and domestic animals on a global scale. Unable to synthesize de novo their own …

An increasing number of crystal structures available on one side, and the boost of
computational power available for computer-aided drug design tasks on the other, have …

The design of small-molecule-binding proteins requires protein backbones that contain
cavities. Previous design efforts were based on naturally occurring cavity-containing …

Fatty acid and retinol binding proteins (FAR) are unique proteins found in nematodes and
are considered potential targets for controlling these parasites. However, their functions in …

Secretory-abundant heat-soluble (SAHS) proteins, which constitute a protein family unique
to tardigrades, are thought to be essential for anhydrobiosis. Our previous study has …

TAK1 is a serine/threonine kinase which is involved in the moderation of cell survival and
death via the TNFα signalling pathway. It is also implicated in a range of cancer and anti …

Dynamics of protein cavities associated with protein fluctuations and conformational
plasticity is essential for their biological function. NMR ensembles, molecular dynamics (MD) …

RNA interference (RNAi) is a powerful tool for the analysis of gene function in nematodes.
Fatty acid and retinol binding protein (FAR) is a protein that only exists in nematodes and …

The COVID-19 pandemic has accelerated the study of drugs, most notably ivermectin and
more recently Paxlovid (PF-07321332) which is in phase III clinical trials with experimental …

O nemátode das lesões radiculares (NLRs) Pratylenchus penetrans é um nemátode
fitoparasita migratório capaz de infetar mais de 400 culturas com interesse agrícola. Em …