Five vascular endothelial growth factor receptor (VEGFR) ligands (VEGF-A,-B,–C,-D, and
placental growth factor [PlGF]) constitute the VEGF family. VEGF-A binds VEGF receptors 1 …

Vascular endothelial growth factor (VEGF) is a secreted mitogen highly specific for cultured
endothelial cells. In vivo VEGF induces microvascular permeability and plays a central role …

Although changes in nucleotide sequence affecting the composition and the structure of
proteins are well known, functional changes resulting from nucleotide substitutions cannot …

Abstract ZD6474 [N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)
methoxy] quinazolin-4-amine] is a potent, po active, low molecular weight inhibitor of kinase …

During bone growth, development, and remodeling, angiogenesis as well as osteogenesis
are closely associated processes, sharing some essential mediators. Vascular endothelial …

Previous work has shown that heterozygocity for a null mutation of the VEGF-A gene,
resulting in a 50% reduction in VEGF-A expression, is embryonic lethal at embroyonic day …

It has been shown that oxygen deprivation results in apoptotic cell death, and that hypoxia
inducible factor 1 (HIF1) and the tumor suppressor p53 play key roles in this process …

A major link between inflammation and cancer is provided by NF-κB transcription factors. Ikk
βΔ hep mice, which specifically lack IκB kinase β (IKKβ), an activator of NF-κB, in …

Over the past few years, mesenchymal stem (or stromal) cells (MSCs) have garnered
enormous interest due to their therapeutic value especially for their multilineage …

Though the ischemic penumbra has been classically described on the basis of blood flow
and physiologic parameters, a variety of ischemic penumbras can be described in molecular …