Ceramides are bioactive sphingolipids that support the structure of the plasma membrane
and mediate numerous cell-signaling events in eukaryotic cells. The finding that ceramides …

In recent decades, many serious respiratory infections have broken out all over the world,
including SARS‐CoV, MERS, and COVID‐19. They are characterized by strong infectivity …

Background & Aims Ceramide, a sphingolipid metabolite, affects T-cell signaling, induces
apoptosis of cancer cells, and slows tumor growth in mice. However, it has not been used as …

Influenza A virus (IAV) employs diverse strategies to circumvent type I interferon (IFN)
responses, particularly by inhibiting the synthesis of type I IFNs. However, it is poorly …

T-cell memory is critical for long-term immunity. However, the factors involved in maintaining
the persistence, function, and phenotype of the memory pool are undefined. Eomesodermin …

Influenza A virus (IAV) is a major human respiratory pathogen causing annual epidemics as
well as periodic pandemics. A complete understanding of the virus pathogenesis and host …

Influenza A virus (IAV) is an important zoonotic pathogen that can cause disease in animals
such as poultry and pigs, and it can cause infection and even death in humans, posing a …

Annual influenza outbreaks are associated with significant morbidity and mortality worldwide
despite the availability of seasonal vaccines. Influenza pathogenesis depends on the …

Following the discovery of ceramide as the central signaling and metabolic relay among
sphingolipids, studies of its involvement in lung health and pathophysiology have …

Influenza continues to pose a threat to public health by causing illness and mortality in
humans. Discovering host factors that regulate influenza virus propagation is vital for the …