Luminescent and photofunctional transition metal complexes: From molecular design to diagnostic and therapeutic applications

LCC Lee, KKW Lo - Journal of the American Chemical Society, 2022 - ACS Publications
There has been emerging interest in the exploitation of the photophysical and
photochemical properties of transition metal complexes for diagnostic and therapeutic …

Shining new light on biological systems: luminescent transition metal complexes for bioimaging and biosensing applications

LCC Lee, KKW Lo - Chemical Reviews, 2024 - ACS Publications
Luminescence imaging is a powerful and versatile technique for investigating cell
physiology and pathology in living systems, making significant contributions to life science …

Near‐infrared‐II light induced mild hyperthermia activate cisplatin‐artemisinin nanoparticle for enhanced chemo/chemodynamic therapy and immunotherapy

G Xiong, D Huang, L Lu, X Luo, Y Wang, S Liu… - Small …, 2022 - Wiley Online Library
Chemodynamic therapy (CDT) is an effective cancer treatment that uses Fenton reaction to
induce cancer cell death. Current clinical applications of CDT are limited by the dependency …

The direct catalytic synthesis of ultrasmall Cu 2 O-coordinated carbon nitrides on ceria for multimodal antitumor therapy

L Cao, Z Feng, R Guo, Q Tian, W Wang, X Rong… - Materials …, 2023 - pubs.rsc.org
Engineering chem-/sono-/photo-multimodal antitumor therapies has become an efficient
strategy to combat malignant tumors. However, the existence of hypoxia in the tumor …

Anticancer profile of coumarin 6-based Ir (iii) photocatalysts under normoxia and hypoxia by ROS generation and NADH oxidation

AK Yadav, A Upadhyay, A Bera, R Kushwaha… - Inorganic Chemistry …, 2024 - pubs.rsc.org
Herein, we have designed, synthesized, and characterized two novel coumarin-6-based Ir
(III) photo-catalysts viz.[Ir (CO6) 2 (dppz)] Cl (Ir1) and [Ir (CO6) 2 (aip)] Cl (Ir2), where CO6 …

Recent advances for enhanced photodynamic therapy: from new mechanisms to innovative strategies

X Wang, J Peng, C Meng, F Feng - Chemical Science, 2024 - pubs.rsc.org
Photodynamic therapy (PDT) has been developed as a potential cancer treatment approach
owing to its non-invasiveness, spatiotemporal control and limited side effects. Currently …

[HTML][HTML] Iridium metal complex targeting oxidation resistance 1 protein attenuates spinal cord injury by inhibiting oxidative stress-associated reactive oxygen species

C Peng, J Luo, K Wang, J Li, Y Ma, J Li, H Yang… - Redox Biology, 2023 - Elsevier
Oxidative stress is a key factor leading to profound neurological deficits following spinal cord
injury (SCI). In this study, we present the development and potential application of an iridium …

Exploring a Mitochondria Targeting, Dinuclear Cyclometalated Iridium (III) Complex for Image-Guided Photodynamic Therapy in Triple-Negative Breast Cancer Cells

N Neelambaran, S Shamjith, VP Murali… - ACS Applied Bio …, 2023 - ACS Publications
Photodynamic therapy (PDT) has emerged as an efficient and noninvasive treatment
approach utilizing laser-triggered photosensitizers for combating cancer. Within this rapidly …

[HTML][HTML] Emergence of Raman spectroscopy as a probing tool for theranostics

R Singh, V Yadav, AK Dhillon, A Sharma… - …, 2023 - ncbi.nlm.nih.gov
Although medical advances have increased our grasp of the amazing morphological,
genetic, and phenotypic diversity of diseases, there are still significant technological barriers …

Mitochondria-targeted cyclometalated iridium-β-carboline complexes as potent non-small cell lung cancer therapeutic agents

J Chen, X Guo, D Li, H Tang, J Gao, W Yu, X Zhu… - Metallomics, 2023 - academic.oup.com
Natural products and metals play a crucial role in cancer research and the development of
antitumor drugs. We designed and synthesized three new carboline-based cyclometalated …