The DNA damage response and cancer therapy
CJ Lord, A Ashworth - Nature, 2012 - nature.com
Genomic instability is one of the most pervasive characteristics of tumour cells and is
probably the combined effect of DNA damage, tumour-specific DNA repair defects, and a …
probably the combined effect of DNA damage, tumour-specific DNA repair defects, and a …
TET proteins and the control of cytosine demethylation in cancer
L Scourzic, E Mouly, OA Bernard - Genome medicine, 2015 - Springer
The discovery that ten-eleven translocation (TET) proteins are α-ketoglutarate-dependent
dioxygenases involved in the conversion of 5-methylcytosines (5-mC) to 5 …
dioxygenases involved in the conversion of 5-methylcytosines (5-mC) to 5 …
Uncovering novel mutational signatures by de novo extraction with SigProfilerExtractor
Mutational signature analysis is commonly performed in cancer genomic studies. Here, we
present SigProfilerExtractor, an automated tool for de novo extraction of mutational …
present SigProfilerExtractor, an automated tool for de novo extraction of mutational …
A first-in-class polymerase theta inhibitor selectively targets homologous-recombination-deficient tumors
DNA polymerase theta (POLθ or POLQ) is synthetic lethal with homologous recombination
(HR) deficiency and is thus a candidate target for HR-deficient cancers. Through high …
(HR) deficiency and is thus a candidate target for HR-deficient cancers. Through high …
Strong suppression of gene conversion with increasing DNA double-strand break load delimited by 53BP1 and RAD52
E Mladenov, C Staudt, A Soni… - Nucleic acids …, 2020 - academic.oup.com
In vertebrates, genomic DNA double-strand breaks (DSBs) are removed by non-
homologous end-joining processes: classical non-homologous end-joining (c-NHEJ) and …
homologous end-joining processes: classical non-homologous end-joining (c-NHEJ) and …
Distinct binding of BRCA2 BRC repeats to RAD51 generates differential DNA damage sensitivity
G Chatterjee, J Jimenez-Sainz, T Presti… - Nucleic Acids …, 2016 - academic.oup.com
BRCA2 is a multi-faceted protein critical for the proper regulation of homology-directed
repair of DNA double-strand breaks. Elucidating the mechanistic features of BRCA2 is …
repair of DNA double-strand breaks. Elucidating the mechanistic features of BRCA2 is …
A Preclinical Trial and Molecularly Annotated Patient Cohort Identify Predictive Biomarkers in Homologous Recombination–deficient Pancreatic Cancer
Purpose: Pancreatic ductal adenocarcinoma (PDAC) arising in patients with a germline
BRCA1 or BRCA2 (g BRCA) mutation may be sensitive to platinum and PARP inhibitors …
BRCA1 or BRCA2 (g BRCA) mutation may be sensitive to platinum and PARP inhibitors …
A whole‐genome massively parallel sequencing analysis of BRCA1 mutant oestrogen receptor‐negative and ‐positive breast cancers
R Natrajan, A Mackay, MB Lambros… - The Journal of …, 2012 - Wiley Online Library
BRCA1 encodes a tumour suppressor protein that plays pivotal roles in homologous
recombination (HR) DNA repair, cell‐cycle checkpoints, and transcriptional regulation …
recombination (HR) DNA repair, cell‐cycle checkpoints, and transcriptional regulation …
The spectrum of genetic variants in hereditary pancreatic cancer includes Fanconi anemia genes
TP Slavin, SL Neuhausen, B Nehoray, M Niell-Swiller… - Familial cancer, 2018 - Springer
Abstract Approximately 5–10% of all pancreatic cancer patients carry a predisposing
mutation in a known susceptibility gene. Since> 90% of patients present with late stage …
mutation in a known susceptibility gene. Since> 90% of patients present with late stage …
[HTML][HTML] DMPC/Chol liposomal copper CX5461 is therapeutically superior to a DSPC/Chol formulation
AWY Leung, KTJ Chen, GM Ryan, M Anantha… - Journal of Controlled …, 2022 - Elsevier
CX5461, a compound initially identified as an RNA polymerase inhibitor and more recently
as a G-quadruplex binder, binds copper to form a complex. Our previous publication showed …
as a G-quadruplex binder, binds copper to form a complex. Our previous publication showed …