Molecular mechanisms of action of novel psychoactive substances (NPS). A new threat for young drug users with forensic-toxicological implications
A Giorgetti, JP Pascali, P Fais, G Pelletti, A Gabbin… - Life, 2021 - mdpi.com
Novel psychoactive substances (NPS) represent a severe health risk for drug users. Even
though the phenomenon has been growing since the early 2000s, the mechanisms of action …
though the phenomenon has been growing since the early 2000s, the mechanisms of action …
Prebiotics modulate the microbiota–gut–brain axis and ameliorate cognitive impairment in APP/PS1 mice
S Zhang, S Lv, Y Li, D Wei, X Zhou, X Niu… - European Journal of …, 2023 - Springer
Purpose Prebiotics, including fructo-oligosaccharides (FOS) and galacto-oligosaccharides
(GOS), stimulate beneficial gut bacteria and may be helpful for patients with Alzheimer's …
(GOS), stimulate beneficial gut bacteria and may be helpful for patients with Alzheimer's …
A molecular analysis of substituted phenylethylamines as potential microtubule targeting agents through in silico methods and in vitro microtubule-polymerization …
IR De Abreu, A Barkdull, JR Munoz, RP Smith… - Scientific Reports, 2023 - nature.com
Natural phenethylamines are trace amine neurotransmitters associated with dopamine
transmission and related illnesses such Parkinson's disease, and addiction. Synthetic …
transmission and related illnesses such Parkinson's disease, and addiction. Synthetic …
Scutellarin modulates the microbiota-gut-brain axis and improves cognitive impairment in APP/PS1 mice
S Zhang, D Wei, S Lv, L Wang, H An… - Journal of …, 2022 - content.iospress.com
Background: Scutellarin, a flavonoid purified from the Chinese herb Erigeron breviscapus,
has been reported to prevent Alzheimer's disease (AD) by affecting Aß assembly. Given the …
has been reported to prevent Alzheimer's disease (AD) by affecting Aß assembly. Given the …
Dysfunction of GluN3A subunit is involved in depression-like behaviors through synaptic deficits
M Zhang, X Kong, J Chen, W Liu, C Liu, X Dou… - Journal of Affective …, 2023 - Elsevier
Background N-methyl-d-aspartate receptor (NMDAR) has been implicated in the
pathophysiology of depression. However, as the unique inhibitory subunit of NMDARs, the …
pathophysiology of depression. However, as the unique inhibitory subunit of NMDARs, the …
Designer Drug, 25D-NBOMe, Has Reinforcing and Rewarding Effects through Change of a Dopaminergic Neurochemical System
JG Lee, KH Hur, SB Hwang, S Lee… - ACS Chemical …, 2023 - ACS Publications
2-(2, 5-Dimethoxy-4-methylphenyl)-N-(2-methoxybenzyl) _ethanamine (25D-NBOMe), an
analogue of the 2C family, is a newly synthesized psychoactive substance. It acts as an …
analogue of the 2C family, is a newly synthesized psychoactive substance. It acts as an …
Serotonin 2C receptors are also important in head-twitch responses in male mice
RJP Custodio, DM Ortiz, HJ Lee, LV Sayson, M Kim… - …, 2023 - Springer
Rationale Serotonergic psychedelics exert their effects via their high affinity for serotonin (5-
HT) receptors, particularly through activating 5-HT2A receptors (5-HT2AR), employing the …
HT) receptors, particularly through activating 5-HT2A receptors (5-HT2AR), employing the …
Transient receptor potential ankyrin 1 channel modulates the abuse‐related mechanisms of methamphetamine through interaction with dopamine transporter
KH Hur, Y Lee, AL Donio, SK Kim… - British Journal of …, 2024 - Wiley Online Library
Background and Purpose Methamphetamine (METH) use disorder has risen dramatically
over the past decade, and there are currently no FDA‐approved medications due, in part, to …
over the past decade, and there are currently no FDA‐approved medications due, in part, to …
Synthesis and Functional Characterization of 2-(2,5-Dimethoxyphenyl)-N-(2-fluorobenzyl)ethanamine (25H-NBF) Positional Isomers
E Pottie, OV Kupriyanova, VA Shevyrin… - ACS Chemical …, 2021 - ACS Publications
Serotonergic psychedelics, substances exerting their pharmacological action through
activation of the serotonin 2A receptor (5-HT2AR), have continuously comprised a …
activation of the serotonin 2A receptor (5-HT2AR), have continuously comprised a …
[HTML][HTML] Abuse potential of synthetic cannabinoids: AM-1248, CB-13, and PB-22
Currently, the expanding recreational use of synthetic cannabinoids (SCBs) threatens public
health. SCBs produce psychoactive effects similar to those of tetrahydrocannabinol, the …
health. SCBs produce psychoactive effects similar to those of tetrahydrocannabinol, the …