The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress
Oxidative stress (OS) disrupts the chemical integrity of macromolecules and increases the
risk of neurodegenerative diseases. Fisetin is a flavonoid that exhibits potent antioxidant …
risk of neurodegenerative diseases. Fisetin is a flavonoid that exhibits potent antioxidant …
Role of endogenous lipopolysaccharides in neurological disorders
Lipopolysaccharide (LPS) is a cell-wall immunostimulatory endotoxin component of Gram-
negative bacteria. A growing body of evidence reveals that alterations in the bacterial …
negative bacteria. A growing body of evidence reveals that alterations in the bacterial …
Neurological enhancement effects of melatonin against brain injury-induced oxidative stress, neuroinflammation, and neurodegeneration via AMPK/CREB signaling
Oxidative stress and energy imbalance strongly correlate in neurodegenerative diseases.
Repeated concussion is becoming a serious public health issue with uncontrollable adverse …
Repeated concussion is becoming a serious public health issue with uncontrollable adverse …
Vanillic acid, a bioactive phenolic compound, counteracts LPS-induced neurotoxicity by regulating c-Jun N-terminal kinase in mouse brain
The receptor for advanced glycation end products (RAGE), a pattern recognition receptor
signaling event, has been associated with several human illnesses, including …
signaling event, has been associated with several human illnesses, including …
Fisetin rescues the mice brains against D-galactose-induced oxidative stress, neuroinflammation and memory impairment
S Ahmad, A Khan, W Ali, MH Jo, J Park… - Frontiers in …, 2021 - frontiersin.org
Herein, we have evaluated the protective potentials of Fisetin against d-galactose-induced
oxidative stress, neuroinflammation, and memory impairment in mice. d-galactose (D-gal) …
oxidative stress, neuroinflammation, and memory impairment in mice. d-galactose (D-gal) …
Anti-oxidative, anti-inflammatory and anti-apoptotic effects of flavonols: targeting Nrf2, NF-κB and p53 pathways in neurodegeneration
Neurodegenerative diseases are one of the leading causes of disability and death
worldwide. Intracellular transduction pathways that end in the activation of specific …
worldwide. Intracellular transduction pathways that end in the activation of specific …
Discovery of anti-inflammatory natural flavonoids: Diverse scaffolds and promising leads for drug discovery
J Li, R Zhao, P Miao, F Xu, J Chen, X Jiang… - European Journal of …, 2023 - Elsevier
Natural products have been utilized for medicinal purposes for millennia, endowing them
with a rich source of chemical scaffolds and pharmacological leads for drug discovery …
with a rich source of chemical scaffolds and pharmacological leads for drug discovery …
Flavonoids as therapeutic candidates for emotional disorders such as anxiety and depression
YH Ko, SK Kim, SY Lee, CG Jang - Archives of pharmacal research, 2020 - Springer
Emotional disorders such as anxiety and depression are widespread psychological
diseases that affect up to 20% of the world's population. There are many approaches to the …
diseases that affect up to 20% of the world's population. There are many approaches to the …
The endotoxin hypothesis of Alzheimer's disease
Lipopolysaccharide (LPS) constitutes much of the surface of Gram-negative bacteria, and if
LPS enters the human body or brain can induce inflammation and act as an endotoxin. We …
LPS enters the human body or brain can induce inflammation and act as an endotoxin. We …
The Neuroprotective Role of Fisetin in Different Neurological Diseases: A Systematic Review
Y Jiang, X Tang, P Deng, C Jiang, Y He, D Hao… - Molecular …, 2023 - Springer
Neurological diseases place a substantial burden on public health and have a serious
impact on the quality of life of patients. Despite the multifaceted pathological process …
impact on the quality of life of patients. Despite the multifaceted pathological process …