Advances in the knowledge of the molecular biology of glioblastoma and its impact in patient diagnosis, stratification, and treatment
B Delgado‐Martín, MÁ Medina - Advanced Science, 2020 - Wiley Online Library
Gliomas are the most common primary brain tumors in adults. They arise in the glial tissue
and primarily occur in the brain. Low‐grade tumors of World Health Organization (WHO) …
and primarily occur in the brain. Low‐grade tumors of World Health Organization (WHO) …
[HTML][HTML] Identifying driver mutations in sequenced cancer genomes: computational approaches to enable precision medicine
High-throughput DNA sequencing is revolutionizing the study of cancer and enabling the
measurement of the somatic mutations that drive cancer development. However, the …
measurement of the somatic mutations that drive cancer development. However, the …
Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations
The majority of patients with neuroblastoma have tumors that initially respond to
chemotherapy, but a large proportion will experience therapy-resistant relapses. The …
chemotherapy, but a large proportion will experience therapy-resistant relapses. The …
Mutual exclusivity analysis identifies oncogenic network modules
Although individual tumors of the same clinical type have surprisingly diverse genomic
alterations, these events tend to occur in a limited number of pathways, and alterations that …
alterations, these events tend to occur in a limited number of pathways, and alterations that …
[HTML][HTML] Genomic landscape of metastatic breast cancer identifies preferentially dysregulated pathways and targets
MR Paul, T Pan, DK Pant, NNC Shih… - The Journal of …, 2020 - Am Soc Clin Investig
Nearly all breast cancer deaths result from metastatic disease. Despite this, the genomic
events that drive metastatic recurrence are poorly understood. We performed whole-exome …
events that drive metastatic recurrence are poorly understood. We performed whole-exome …
The genetic landscape of the childhood cancer medulloblastoma
DW Parsons, M Li, X Zhang, S Jones, RJ Leary… - science, 2011 - science.org
Medulloblastoma (MB) is the most common malignant brain tumor of children. To identify the
genetic alterations in this tumor type, we searched for copy number alterations using high …
genetic alterations in this tumor type, we searched for copy number alterations using high …
De novo discovery of mutated driver pathways in cancer
Next-generation DNA sequencing technologies are enabling genome-wide measurements
of somatic mutations in large numbers of cancer patients. A major challenge in the …
of somatic mutations in large numbers of cancer patients. A major challenge in the …
[HTML][HTML] Simultaneous identification of multiple driver pathways in cancer
MDM Leiserson, D Blokh, R Sharan… - PLoS computational …, 2013 - journals.plos.org
Distinguishing the somatic mutations responsible for cancer (driver mutations) from random,
passenger mutations is a key challenge in cancer genomics. Driver mutations generally …
passenger mutations is a key challenge in cancer genomics. Driver mutations generally …
Exome sequencing identifies MXRA5 as a novel cancer gene frequently mutated in non–small cell lung carcinoma from Chinese patients
D Xiong, G Li, K Li, Q Xu, Z Pan, F Ding… - …, 2012 - academic.oup.com
Lung cancer has become the top killer among malignant tumors in China and is significantly
associated with somatic genetic alterations. We performed exome sequencing of 14 non …
associated with somatic genetic alterations. We performed exome sequencing of 14 non …
Expanding the computational toolbox for mining cancer genomes
High-throughput DNA sequencing has revolutionized the study of cancer genomics with
numerous discoveries that are relevant to cancer diagnosis and treatment. The latest …
numerous discoveries that are relevant to cancer diagnosis and treatment. The latest …