ROS-triggered endothelial cell death mechanisms: Focus on pyroptosis, parthanatos, and ferroptosis

D Zheng, J Liu, H Piao, Z Zhu, R Wei, K Liu - Frontiers in immunology, 2022 - frontiersin.org
The endothelium is a single layer of epithelium covering the surface of the vascular system,
and it represents a physical barrier between the blood and vessel wall that plays an …

[HTML][HTML] Rationale for the use of N‐acetylcysteine in both prevention and adjuvant therapy of COVID‐19

S De Flora, R Balansky, S La Maestra - The FASEB journal, 2020 - ncbi.nlm.nih.gov
COVID‐19 may cause pneumonia, acute respiratory distress syndrome, cardiovascular
alterations, and multiple organ failure, which have been ascribed to a cytokine storm, a …

New insights into the role of mitochondria in cardiac microvascular ischemia/reperfusion injury

J Wang, S Toan, H Zhou - Angiogenesis, 2020 - Springer
As reperfusion therapies have become more widely used in acute myocardial infarction
patients, ischemia-induced myocardial damage has been markedly reduced, but reperfusion …

Mitochondrial glutathione: recent insights and role in disease

M Marí, E de Gregorio, C de Dios, V Roca-Agujetas… - Antioxidants, 2020 - mdpi.com
Mitochondria are the main source of reactive oxygen species (ROS), most of them deriving
from the mitochondrial respiratory chain. Among the numerous enzymatic and non …

Sex-specific neurotoxic effects of heavy metal pollutants: Epidemiological, experimental evidence and candidate mechanisms

M Gade, N Comfort, DB Re - Environmental research, 2021 - Elsevier
The heavy metals lead (Pb), mercury (Hg), and cadmium (Cd) are ubiquitous environmental
pollutants and are known to exert severe adverse impacts on the nervous system even at …

[HTML][HTML] Sex differences in markers of oxidation and inflammation. Implications for ageing

IM de Toda, M González-Sánchez… - Mechanisms of ageing …, 2023 - Elsevier
Sexual dimorphism is a key factor to consider in the ageing process given the impact that it
has on life expectancy. The oxidative-inflammatory theory of ageing states that the ageing …

Alterations in glutathione redox homeostasis among adolescents with obesity and anemia

D Alkazemi, A Rahman, B Habra - Scientific reports, 2021 - nature.com
Abstract The reduced (GSH)-to-oxidized (GSSG) glutathione ratio represents a dynamic
balance between oxidants and antioxidants. However, redox status in adolescents with …

Oxidative stress as a common key event in developmental neurotoxicity

Y Nishimura, Y Kanda, H Sone… - Oxidative medicine and …, 2021 - Wiley Online Library
The developing brain is extremely sensitive to many chemicals. Perinatal exposure to
neurotoxicants has been implicated in several neurodevelopmental disorders, including …

Fluorescent sensing of glutathione and related bio-applications

X Sun, F Guo, Q Ye, J Zhou, J Han, R Guo - Biosensors, 2022 - mdpi.com
Glutathione (GSH), as the most abundant low-molecular-weight biological thiol, plays
significant roles in vivo. Abnormal GSH levels have been demonstrated to be related to the …

[HTML][HTML] The age-dependent decline of the extracellular thiol-disulfide balance and its role in SARS-CoV-2 infection

D Giustarini, A Santucci, D Bartolini, F Galli, R Rossi - Redox Biology, 2021 - Elsevier
Abstract SARS–CoV-2 (COVID-19) infection can cause a severe respiratory distress
syndrome. The risk of severe manifestations and mortality characteristically increase in the …