The biological effects of cannabinoids, the major constituents of the ancient medicinal plant
Cannabis sativa (marijuana) are mediated by two members of the G-protein coupled …

Apart from having been used and misused for at least four millennia for, among others,
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …

Endocannabinoids (eCBs) are amongst the most ubiquitous signaling molecules in the
nervous system. Over the past few decades, observations based on a large volume of work …

Summary Δ 9-tetrahydrocannabinol (THC) and its sibling, cannabidiol (CBD), are produced
by the same Cannabis plant and have similar chemical structures but differ dramatically in …

Hypothalamic pro-opiomelanocortin (POMC) neurons promote satiety. Cannabinoid
receptor 1 (CB 1 R) is critical for the central regulation of food intake. Here we test whether …

Endocannabinoids and cannabinoid CB1 receptors are known to play a generalized role in
energy homeostasis. However, clinical trials with the first generation of CB1 blockers, now …

Cannabis use disorder (CUD) is widespread, and there is no pharmacotherapy to facilitate
its treatment. AEF0117, the first of a new pharmacological class, is a signaling-specific …

The mammalian brain is one of the organs with the highest energy demands, and
mitochondria are key determinants of its functions. Here we show that the type-1 …

Despite being regarded as a hippie science for decades, cannabinoid research has finally
found its well-deserved position in mainstream neuroscience. A series of groundbreaking …

Chronic cannabis (marijuana, hashish) smoking can result in dependence. Rodent studies
show reversible downregulation of brain cannabinoid CB 1 (cannabinoid receptor type 1) …