Generation of neurotoxic amyloid β peptides and their deposition along with neurofibrillary
tangle formation represent key pathological hallmarks in Alzheimer's disease (AD). Recent …

Generation and deposition of amyloid beta peptides and neurofibrillary tangle formation are
key mechanisms involved in AD pathogenesis. Recent evidence suggests that inflammatory …

The members of the chromogranin–secretogranin family of peptide hormones, biogenic
amines, and neurotransmitters are enclosed within vesicles in the neuroendocrine system …

Dopaminergic neurons of the substantia nigra are particularly vulnerable to oxidative and
inflammatory attack. Such processes may play a crucial role in the etiology of Parkinson …

The immunohistochemical demonstration of reactive microglia and activated complement
components suggests that chronic inflammation occurs in affected brain regions in …

Disease heterogeneity has been a critical challenge for precision diagnosis and treatment,
especially in neurologic and neuropsychiatric diseases. Many diseases can display multiple …

Neuroinflammation is a host‐defense mechanism associated with restoration of normal
structure and function of the brain and neutralization of an insult. Increasing …

Microglia are perhaps the most underestimated cell type of our immune system. Not only
were immunologists unaware of their capabilities until recently, but also, some …

Here we report that chromogranins, components of neurosecretory vesicles, interact with
mutant forms of superoxide dismutase (SOD1) that are linked to amyotrophic lateral …

Activated microglia may be detrimental to neuronal survival in a number of
neurodegenerative diseases. Thus, strategies that reduce microglial neurotoxicity may have …