Contribution of epididymal epithelial cell functions to sperm epigenetic changes and the health of progeny

H Chen, MBR Alves… - Human reproduction …, 2022 - academic.oup.com
BACKGROUND Spermatozoa acquire their motility and fertilizing abilities during their
maturation through the epididymis. This process is controlled by epididymal epithelial cells …

[HTML][HTML] Exosomes: New regulators of reproductive development

C Chen, Z Zhang, X Gu, X Sheng, L Xiao, X Wang - Materials Today Bio, 2023 - Elsevier
Exosomes are a subtype of extracellular vesicles (EVs) with a size range between 30 and
150​ nm, which can be released by the majority of cell types and circulate in body fluid …

Regulatory T cells play a crucial role in maintaining sperm tolerance and male fertility

F Barrachina, K Ottino, ML Elizagaray… - Proceedings of the …, 2023 - National Acad Sciences
Regulatory T cells (Tregs) modulate tissue homeostatic processes and immune responses.
Understanding tissue-Treg biology will contribute to developing precision-targeting …

Extracellular vesicles in seminal fluid and effects on male reproduction. An overview in farm animals and pets

J Roca, H Rodriguez-Martinez, L Padilla… - Animal Reproduction …, 2022 - Elsevier
Extracellular vesicles (EVs) are lipid bilayer nanovesicles released by most functional cells
to body fluids, containing bioactive molecules, mainly proteins, lipids, and nucleic acids …

sncRNAs in epididymosomes: the contribution to embryonic development and offspring health

J Luo, X Tan, H Li, X Ding - International Journal of Molecular Sciences, 2022 - mdpi.com
Much progress has been made in determining that paternal environmental exposures can
remodel their spermatozoa small noncoding RNAs (sncRANs) and, in turn, affect the …

HA-tag CD63 is a novel conditional transgenic approach to track extracellular vesicle interactions with sperm and their transfer at conception

CP Morgan, VE Meadows, R Marx-Rattner, YM Cisse… - Scientific reports, 2023 - nature.com
Extracellular vesicles (EVs) are a unique mode of intercellular communication capable of
specificity in transmitting signals and cargo to coordinate local and distant cellular functions …

Proteomic analysis of koala (phascolarctos cinereus) spermatozoa and prostatic bodies

DA Skerrett‐Byrne, AL Anderson, L Hulse, C Wass… - …, 2021 - Wiley Online Library
The aims of this study were to investigate the proteome of koala spermatozoa and that of the
prostatic bodies with which they interact during ejaculation. For this purpose, spermatozoa …

Immortalized mouse caput epididymal epithelial (mECap18) cell line recapitulates the in‐vivo environment

JE Mulhall, NA Trigg, IR Bernstein, AL Anderson… - …, 2024 - Wiley Online Library
Residing between the testes and the vas deferens, the epididymis is a highly convoluted
tubule whose unique luminal microenvironment is crucial for the functional maturation of …

Phosphoproteomic analysis of the adaption of epididymal epithelial cells to corticosterone challenge

DA Skerrett‐Byrne, SJ Stanger, NA Trigg… - …, 2024 - Wiley Online Library
Background The epididymis has long been of interest owing to its role in promoting the
functional maturation of the male germline. More recent evidence has also implicated the …

The efficacy and functional consequences of interactions between human spermatozoa and seminal fluid extracellular vesicles

CT Tamessar, AL Anderson… - Reproduction and …, 2024 - raf.bioscientifica.com
Seminal fluid extracellular vesicles (SFEVs) have previously been shown to interact with
spermatozoa and influence their fertilisation capacity. Here, we sought to extend these …