The regulation of transcription by RNA polymerase II is closely intertwined with the
regulation of chromatin structure. A host of proteins required for the disassembly …

Intracellular innate immunity involves co-evolved antiviral restriction factors that specifically
inhibit infecting viruses. Studying these restrictions has increased our understanding of viral …

The polymerase-associated factor 1 (Paf1) complex (Paf1C) is a conserved protein complex
with critical functions during eukaryotic transcription. Previous studies showed that Paf1C is …

Transcription elongation has emerged as a regulatory hub in gene expression of
metazoans. A major control point occurs during early elongation before RNA polymerase II …

The absorption of cadmium (Cd) initiates a sequence of detrimental effects or harm to
organisms. The presence of Cd in Saccharomyces cerevisiae affects key metal import …

Gene expression is dependent on RNA Polymerase II (Pol II) activity in eukaryotes. In
addition to determining the rate of RNA synthesis for all protein coding genes, Pol II serves …

Phosphoribosyl pyrophosphate synthetase (PRS EC 2.7. 6.1) is a rate-limiting enzyme that
irreversibly catalyzes the formation of phosphoribosyl pyrophosphate (PRPP) from ribose-5 …

RNA-binding proteins (RBPs) are key mediators of RNA metabolism. Whereas some RBPs
exhibit narrow transcript specificity, others function broadly across both coding and non …

Compared to other stages in the RNA polymerase II transcription cycle, the role of chromatin
in transcription termination is poorly understood. We performed a genetic screen in …

Spliceosome assembly contributes an important but incompletely understood aspect of
splicing regulation. Prp45 is a yeast splicing factor which runs as an extended fold through …