Most patients diagnosed with head and neck squamous cell carcinoma (HNSCC) will
present with locally advanced disease, requiring multimodality therapy. While this approach …

The most common cancer caused by human papillomavirus (HPV) infection in the United
States is oropharyngeal cancer (OPC), and its incidence has been rising since the turn of the …

The NCCN Guidelines for Head and Neck Cancers address tumors arising in the oral cavity
(including mucosal lip), pharynx, larynx, and paranasal sinuses. Occult primary cancer …

Importance The optimal approach for treatment deescalation in human papillomavirus (HPV)–
related oropharyngeal squamous cell carcinomas (OPSCCs) is unknown. Objective To …

Background Pretreatment identification of pathological extranodal extension (ENE) would
guide therapy de-escalation strategies for in human papillomavirus (HPV)-associated …

Background There is significant interest in treatment de-escalation for human papillomavirus-
associated (HPV+) oropharyngeal squamous cell carcinoma (OPSCC) patients given the …

Background Recipients of radiation therapy (RT) for head and neck cancer (HNC) are at
significantly increased risk for carotid artery stenosis (CAS) and cerebrovascular disease …

Minimally invasive surgery is a growing field in surgical oncology. After acquiring its first
Food and Drug Administration approval in 2009 for T1–T2 malignancies of the oral cavity …

Background Head and neck cancers (HNCs) are very common malignancies, and treatment
often requires multimodal approaches, including radiotherapy and chemotherapy. Patients …

The prevalence of oropharyngeal squamous cell carcinoma has been increasing in North
America due to human papillomavirus-associated disease. It is molecularly distinct and …