Abstract The International Index of Erectile Function (IIEF) is a widely used, multi-
dimensional self-report instrument for the evaluation of male sexual function. It is has been …

Erection is basically a spinal reflex that can be initiated by recruitment of penile afferents, but
also by visual, olfactory, and imaginary stimuli. The reflex involves both autonomic and …

Background and aims After a series of seminal works during the last decade of the 20th
century, nitric oxide (NO) is now firmly placed in the pantheon of plant signals. Nitric oxide …

The clinical properties (efficacy and safety profile) of a medicine are related not only to its
mode of action, but also to its selectivity for its target (usually a receptor or enzyme) and are …

Phosphodiesterases (PDEs) play a decisive role in cyclic nucleotide-mediated intracellular
signaling. As PDEs are expressed in a variety of tissues, selectivity is a prerequisite for a …

Preeclampsia is one of the most serious pregnancy-specific medical conditions of increasing
incidence. It remains a major cause of maternal and fetal morbidity and mortality. Although …

Inheritance of a single copy of the gene encoding huntingtin (HD) with an expanded
polyglutamine-encoding CAG repeat leads to neuronal dysfunction, neurodegeneration and …

Tuberculosis (TB) is an infectious disease caused by an obligate intracellular pathogen,
Mycobacterium tuberculosis (M. tb) and is responsible for the maximum number of deaths …

Preeclampsia is a serious, pregnancy-specific, multi-organ disease process of compound
aetiology. It affects 3–6% of expecting mothers worldwide and it persists as a leading cause …

Objective To assess the efficacy and safety of daily tadalafil, a potent selective
phosphodiesterase 5 inhibitor, for the treatment of erectile dysfunction (ED) in men …