The dorsolateral prefrontal cortex (DLPFC) is a functionally and structurally heterogeneous
region and a key node of several brain networks, implicated in cognitive, affective, and …

Neuropathic pain can develop after nerve injury, when deleterious changes occur in injured
neurons and along nociceptive and descending modulatory pathways in the central nervous …

A thought-provoking argument that consciousness—more widespread than previously
assumed—is the feeling of being alive, not a type of computation or a clever hack In The …

Background Persistent pain is measured by means of self-report, the sole reliance on which
hampers diagnosis and treatment. Functional magnetic resonance imaging (fMRI) holds …

Non-invasive functional brain imaging is used more than ever to investigate pain in health
and disease, with the prospect of finding new means to alleviate pain and improve patient …

It has been argued that emotion, pain and cognitive control are functionally segregated in
distinct subdivisions of the cingulate cortex. However, recent observations encourage a …

The pain matrix is conceptualised here as a fluid system composed of several interacting
networks. A nociceptive matrix receiving spinothalamic projections (mainly posterior …

Neuroimaging and neurophysiological studies have shown that nociceptive stimuli elicit
responses in an extensive cortical network including somatosensory, insular and cingulate …

Stress is present in everyday life in various forms and situations. Two stressors frequently
investigated are physiological and psychosocial stress. Besides similar subjective and …

Pain diagnosis and management would benefit from the development of objective markers
of nociception and pain. Current research addressing this issue has focused on five main …